MABP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MABP1_MOUSE
• UniProt AC: Q6NS57
• Protein Name: Mitogen-activated protein kinase-binding protein 1
• Gene Name: Mapkbp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1503
• Subcellular Localization: Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle pole . Not detected in the cilium. Localized around the poles of the mitotic spindle from prophase to anaphase in mitotic cells.
• Protein Description: Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (By similarity). Involved in JNK signaling pathway. [PubMed: 10471813]
• Protein Sequence: MMAGEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGVTVSGGRGLACDPRSGLVAYSAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACGRGEKADSTFCITSSGLLCEFSDRRLLDKWVELRTTVAHCISVTQEYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIASITEASRLFSGGVNARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEIKDSHQACLPPSSFITCSSDNTIRLWNTESSGVHGSTLHRNILSNDLIKIIYVDGNTQALLDTELPGGDKADGSLMDPRVGIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGEGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGIKQQGPTSPQRASGAKQHHAPVVPPSGPALSSDSDKEGEDEGTEEEELPALPILSKSTKKELASGSSPALLRSLSHWEMSRAQETMEYLDPAPVANTGPKRRGRWAQPGVELSVRSMLDLRQIETLAPSPRGPSQDSLAVSPAGPGKHGPQGPELSCVSQNERAPRLQTSQPCSCPHIIQLLSQEEGVFAQDLEPAPIEDGIVYPEPSDSPTMDTSAFQVQAPTGGSLGRMYPGSRGSEKHSPDSACSVDYSSSRLSSPEHPNEDSESTEPLSVDGISSDLEEPAEGDEDEEEEGGTGLCGLQEGGPHTPDQEQFLKQHFETLANGTAPGGPARVLERTESQSISSRFLLQVQTSPLREPSLSSSGLALTSRPDQVSQVSGEQLKGSGATPPGAPPEMEPSSGNSGPKQVAPVLLTRRHNNLDNSWASKKMAATRPLAGLQKAQSVHSLVPQDEVPSSRPLLFQEAETQGSLGSLPQAGGCSSQPHSYQNHTTSSMAKLARSISVGENPGLATEPQAPVPIRISPFNKLALPSRAHLVLDIPKPLPDRPTLTTFSPVSKGLAHNETEQSGPLVSLGKAHTTVEKHSCLGEGTTHKSRTECQAYPGPNHPCAQQLPVNNLLQGPESLQPLSPEKTRNPVESSRPGVALSQDSELALSLQQCEQLVAELQGNVRQAVELYRAVTSYKTPSAEQSHITRLLRDTFSSVRQELEVLAGAVLSSPGGSPGAVGAEQTQALLEQYSELLLRAVERRMERRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	RIKNLLRSPSIKLRR HHHHHHCCCCCEEEC	23.98	30372032
21	Phosphorylation	KNLLRSPSIKLRRSK HHHHCCCCCEEECCC	33.33	26160508
483	Phosphorylation	GIRSVCISPNGQHLA CCEEEEECCCCCCCC	13.74	-
536	Phosphorylation	TGLKLLASASRDRLI HHHHHHHHHCCCCEE	27.09	21454597
538	Phosphorylation	LKLLASASRDRLIHV HHHHHHHCCCCEEEE	32.02	27149854
603	Phosphorylation	SGEGVQFTRTHHVVR CCCCCEEEEEEEEEE	19.98	28059163
613	Phosphorylation	HHVVRKTTLYDMDVE EEEEEEEEEEECCCC	26.76	25521595
615	Phosphorylation	VVRKTTLYDMDVEPS EEEEEEEEECCCCCC	13.71	25521595
755	Phosphorylation	GIKQQGPTSPQRASG HHHHHCCCCHHHCCC	60.92	29550500
756	Phosphorylation	IKQQGPTSPQRASGA HHHHCCCCHHHCCCC	23.36	25266776
761	Phosphorylation	PTSPQRASGAKQHHA CCCHHHCCCCCCCCC	41.28	29514104
774	Phosphorylation	HAPVVPPSGPALSSD CCCCCCCCCCCCCCC	51.87	26643407
779	Phosphorylation	PPSGPALSSDSDKEG CCCCCCCCCCCCCCC	33.92	26643407
780	Phosphorylation	PSGPALSSDSDKEGE CCCCCCCCCCCCCCC	41.82	26643407
782	Phosphorylation	GPALSSDSDKEGEDE CCCCCCCCCCCCCCC	53.16	26643407
791	Phosphorylation	KEGEDEGTEEEELPA CCCCCCCCCHHHCCC	37.87	25195567
812	Phosphorylation	STKKELASGSSPALL HCHHHHHCCCCHHHH	52.40	25293948
814	Phosphorylation	KKELASGSSPALLRS HHHHHCCCCHHHHHH	30.56	28066266
815	Phosphorylation	KELASGSSPALLRSL HHHHCCCCHHHHHHH	20.09	26824392
823	Phosphorylation	PALLRSLSHWEMSRA HHHHHHHHHHHHHHH	28.00	29514104
836	Phosphorylation	RAQETMEYLDPAPVA HHHHHHHHCCCCCCC	12.94	29514104
864	Phosphorylation	GVELSVRSMLDLRQI CCCCEECCCCCHHHH	22.88	-
877	Phosphorylation	QIETLAPSPRGPSQD HHHHCCCCCCCCCCC	22.94	29514104
882	Phosphorylation	APSPRGPSQDSLAVS CCCCCCCCCCCCCCC	49.82	24759943
885	Phosphorylation	PRGPSQDSLAVSPAG CCCCCCCCCCCCCCC	15.59	30635358
889	Phosphorylation	SQDSLAVSPAGPGKH CCCCCCCCCCCCCCC	11.92	26824392
983	Phosphorylation	LGRMYPGSRGSEKHS CCCCCCCCCCCCCCC	29.03	30635358
986	Phosphorylation	MYPGSRGSEKHSPDS CCCCCCCCCCCCCCC	42.22	23684622
990	Phosphorylation	SRGSEKHSPDSACSV CCCCCCCCCCCCCCC	41.28	23684622
993	Phosphorylation	SEKHSPDSACSVDYS CCCCCCCCCCCCCCC	34.26	23684622
996	Phosphorylation	HSPDSACSVDYSSSR CCCCCCCCCCCCCCC	20.10	23684622
999	Phosphorylation	DSACSVDYSSSRLSS CCCCCCCCCCCCCCC	14.32	30635358
1089	Phosphorylation	RVLERTESQSISSRF HEEEECCCCCCHHHH	28.72	29899451
1102	Phosphorylation	RFLLQVQTSPLREPS HHHEEEECCCCCCCC	33.19	25521595
1103	Phosphorylation	FLLQVQTSPLREPSL HHEEEECCCCCCCCC	12.59	25293948
1109	Phosphorylation	TSPLREPSLSSSGLA CCCCCCCCCCCCCEE	35.81	25293948
1111	Phosphorylation	PLREPSLSSSGLALT CCCCCCCCCCCEECC	27.13	25293948
1112	Phosphorylation	LREPSLSSSGLALTS CCCCCCCCCCEECCC	33.45	25293948
1113	Phosphorylation	REPSLSSSGLALTSR CCCCCCCCCEECCCC	34.16	25293948
1138	Phosphorylation	QLKGSGATPPGAPPE CCCCCCCCCCCCCCC	33.28	25338131
1166	Dimethylation	APVLLTRRHNNLDNS HHHHEECCCCCCCCC	31.48	-
1166	Methylation	APVLLTRRHNNLDNS HHHHEECCCCCCCCC	31.48	18966269
1193	Phosphorylation	AGLQKAQSVHSLVPQ CHHHHHHHHHHCCCC	27.02	27681418
1250	Phosphorylation	SMAKLARSISVGENP HHHHHHHHCCCCCCC	17.38	25266776
1252	Phosphorylation	AKLARSISVGENPGL HHHHHHCCCCCCCCC	25.89	25266776
1261	Phosphorylation	GENPGLATEPQAPVP CCCCCCCCCCCCCCC	53.92	25293948
1272	Phosphorylation	APVPIRISPFNKLAL CCCCEEECCCCCCCC	17.37	25293948
1378	Phosphorylation	PESLQPLSPEKTRNP CCCCCCCCCCCCCCC	37.38	25293948
1432	Phosphorylation	LYRAVTSYKTPSAEQ HHHHHHCCCCCCHHH	14.98	24719451
1436	Phosphorylation	VTSYKTPSAEQSHIT HHCCCCCCHHHHHHH	50.06	24719451
1443	Phosphorylation	SAEQSHITRLLRDTF CHHHHHHHHHHHHHH	15.16	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MABP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MABP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MABP1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MABP1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.