MA1C1_HUMAN - dbPTM
MA1C1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MA1C1_HUMAN
UniProt AC Q9NR34
Protein Name Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC
Gene Name MAN1C1
Organism Homo sapiens (Human).
Sequence Length 630
Subcellular Localization Golgi apparatus membrane
Single-pass type II membrane protein.
Protein Description Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc..
Protein Sequence MLMRKVPGFVPASPWGLRLPQKFLFLLFLSGLVTLCFGALFLLPHSSRLKRLFLAPRTQQPGLEVVAEIAGHAPAREQEPPPNPAPAAPAPGEDDPSSWASPRRRKGGLRRTRPTGPREEATAARGNSIPASRPGDEGVPFRFDFNAFRSRLRHPVLGTRADESQEPQSQVRAQREKIKEMMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFGGLSGATVIDSLDTLYLMELKEEFQEAKAWVGESFHLNVSGEASLFEVNIRYIGGLLSAFYLTGEEVFRIKAIRLGEKLLPAFNTPTGIPKGVVSFKSGNWGWATAGSSSILAEFGSLHLEFLHLTELSGNQVFAEKVRNIRKVLRKIEKPFGLYPNFLSPVSGNWVQHHVSVGGLGDSFYEYLIKSWLMSGKTDMEAKNMYYEALEAIETYLLNVSPGGLTYIAEWRGGILDHKMGHLACFSGGMIALGAEDAKEEKRAHYRELAAQITKTCHESYARSDTKLGPEAFWFNSGREAVATQLSESYYILRPEVVESYMYLWRQTHNPIYREWGWEVVLALEKYCRTEAGFSGIQDVYSSTPNHDNKQQSFFLAETLKYLYLLFSEDDLLSLEDWVFNTEAHPLPVNHSDSSGRAWGRH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
58O-linked_GlycosylationRLFLAPRTQQPGLEV
HHHCCCCCCCCCCHH		30.42OGP
98O-linked_GlycosylationPGEDDPSSWASPRRR
CCCCCCCCCCCCCCC		31.86OGP
115PhosphorylationGLRRTRPTGPREEAT
CCCCCCCCCCHHHHH		57.4328258704
122PhosphorylationTGPREEATAARGNSI
CCCHHHHHHHCCCCC		24.9128258704
128PhosphorylationATAARGNSIPASRPG
HHHHCCCCCCCCCCC		32.54-
128O-linked_GlycosylationATAARGNSIPASRPG
HHHHCCCCCCCCCCC		32.5455834205
132O-linked_GlycosylationRGNSIPASRPGDEGV
CCCCCCCCCCCCCCC		33.3816964243
132PhosphorylationRGNSIPASRPGDEGV
CCCCCCCCCCCCCCC		33.3816964243
159PhosphorylationLRHPVLGTRADESQE
HCCCCCCCCCCCCCC		20.65-
164PhosphorylationLGTRADESQEPQSQV
CCCCCCCCCCCHHHH		40.1523911959
169PhosphorylationDESQEPQSQVRAQRE
CCCCCCHHHHHHHHH		41.1625954137
207PhosphorylationRPLTKDGYEGNMFGG
CCCCCCCCCCCCCCC		30.6922210691
223PhosphorylationSGATVIDSLDTLYLM
CCCCHHHCHHHHHHH		19.6122210691
226PhosphorylationTVIDSLDTLYLMELK
CHHHCHHHHHHHHHH		23.6922210691
250N-linked_GlycosylationVGESFHLNVSGEASL
CCCCEEEEECCCCEE		19.83UniProtKB CARBOHYD
264PhosphorylationLFEVNIRYIGGLLSA
EEEEEHHHHHHHHHH		10.5022817900
297PhosphorylationKLLPAFNTPTGIPKG
CCHHHCCCCCCCCCC		18.7728258704
403PhosphorylationLIKSWLMSGKTDMEA
HHHHHHHCCCCCHHH		34.6624719451
447AcetylationRGGILDHKMGHLACF
CCCCCCCCCCEEEHH		46.367663145
492PhosphorylationCHESYARSDTKLGPE
HHHHHCCCCCCCCCC		41.2724719451
505PhosphorylationPEAFWFNSGREAVAT
CCEEEECCCHHHHHH		29.7428857561
528PhosphorylationLRPEVVESYMYLWRQ
ECHHHHHHHHHHHHH		12.0023898821
529PhosphorylationRPEVVESYMYLWRQT
CHHHHHHHHHHHHHC		4.0123898821
531PhosphorylationEVVESYMYLWRQTHN
HHHHHHHHHHHHCCC		8.5523898821
536PhosphorylationYMYLWRQTHNPIYRE
HHHHHHHCCCHHHHH		18.2923898821
541PhosphorylationRQTHNPIYREWGWEV
HHCCCHHHHHHCHHH		12.0723898821
554AcetylationEVVLALEKYCRTEAG
HHHHHHHHHHCCCCC		50.9620167786
618N-linked_GlycosylationEAHPLPVNHSDSSGR
CCCCCCCCCCCCCCC		27.31UniProtKB CARBOHYD
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MA1C1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MA1C1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MA1C1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MA1C1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MA1C1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132, AND MASSSPECTROMETRY.

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