M4K3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: M4K3_RAT
• UniProt AC: Q924I2
• Protein Name: Mitogen-activated protein kinase kinase kinase kinase 3
• Gene Name: Map4k3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 873
• Protein Description: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (By similarity)..
• Protein Sequence: MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHANIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKLKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQPLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIPSTSRNVREEKTRSEINFGQVKFDPPLRKETEPHHELDLQLEYGQGHQSNYFLGGNKSLLKSVEEELHQRGHVAHLEDDEGDDDDSKHSTLKAKVPPPLPPKPKSISIPQDTHSSEDSNQGTIKRCPSSGSPAKPSHVPPRPPPPRLPPQKPAVLGNGVSSFQLNGERDGSVHQQQSEQRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCATSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSVSGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFAVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIEFPMPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEISDNTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNPGFDLS -------CCCCCCCC	14.24	-
31	Phosphorylation	SGTYGDVYKARNVNT CCCCCCEEEEECCCC	12.04	-
102	Phosphorylation	GGSLQDIYHVTGPLS CCCHHHHHEECCCHH	9.87	-
327	Phosphorylation	RNVREEKTRSEINFG CCCCCHHHHCCCCCC	42.58	27097102
329	Phosphorylation	VREEKTRSEINFGQV CCCHHHHCCCCCCCC	48.32	27097102
373	Phosphorylation	YFLGGNKSLLKSVEE EEECCCHHHHHHHHH	42.82	28432305
377	Phosphorylation	GNKSLLKSVEEELHQ CCHHHHHHHHHHHHH	34.43	28432305
401	Phosphorylation	DEGDDDDSKHSTLKA CCCCCCCCCCCCCCC	38.98	25575281
404	Phosphorylation	DDDDSKHSTLKAKVP CCCCCCCCCCCCCCC	38.89	25575281
405	Phosphorylation	DDDSKHSTLKAKVPP CCCCCCCCCCCCCCC	31.81	25575281
430	Phosphorylation	IPQDTHSSEDSNQGT CCCCCCCCCCCCCCC	37.51	30181290
433	Phosphorylation	DTHSSEDSNQGTIKR CCCCCCCCCCCCEEE	27.31	30181290
437	Phosphorylation	SEDSNQGTIKRCPSS CCCCCCCCEEECCCC	17.35	30181290
443	Phosphorylation	GTIKRCPSSGSPAKP CCEEECCCCCCCCCC	51.46	27097102
444	Phosphorylation	TIKRCPSSGSPAKPS CEEECCCCCCCCCCC	28.56	27097102
446	Phosphorylation	KRCPSSGSPAKPSHV EECCCCCCCCCCCCC	24.51	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of M4K3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of M4K3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of M4K3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SHLB1_HUMAN	SH3GLB1	physical	11384986

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.