M3K8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: M3K8_MOUSE
• UniProt AC: Q07174
• Protein Name: Mitogen-activated protein kinase kinase kinase 8
• Gene Name: Map3k8
• Organism: Mus musculus (Mouse).
• Sequence Length: 467
• Subcellular Localization: Cytoplasm.
• Protein Description: Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle..
• Protein Sequence: MEYMSTGSDEKEEIDLLIKHLNVSEVIDIMENLYASEEPGVYEPSLMTMYPDSNQNEERSESLLRSGQEVPWLSSVRYGTVEDLLAFANHVSNMTKHFYGRRPQECGILLNMVISPQNGRYQIDSDVLLVPWKLTYRNIGSGFVPRGAFGKVYLAQDMKTKKRMACKLIPIDQFKPSDVEIQACFRHENIAELYGAVLWGDTVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHILKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVKMTEDVYLPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIAGDCSPGMRELIEAALERNPNHRPKAADLLKHEALNPPREDQPRCQSLDSALFERKRLLSRKELQLPENIADSSCTGSTEESEVLRRQRSLYIDLGALAGYFNIVRGPPTLEYG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Phosphorylation	QNEERSESLLRSGQE CCHHHHHHHHHCCCC	33.67	-
80	Phosphorylation	LSSVRYGTVEDLLAF CCCCCCCCHHHHHHH	16.28	-
141	Phosphorylation	LTYRNIGSGFVPRGA CEECCCCCCCCCCCC	25.84	26824392
290	Phosphorylation	LPKDLRGTEIYMSPE CCCCCCCCEEEECCE	16.87	22817900
336	Phosphorylation	KRYPRSAYPSYLYII HCCCCCCCCCEEEEE	8.24	28576409
400	Phosphorylation	EDQPRCQSLDSALFE CCCCCHHCHHHHHHH	37.46	22817900
413	Phosphorylation	FERKRLLSRKELQLP HHHHHHHCHHHHCCC	45.99	22817900
431	Phosphorylation	ADSSCTGSTEESEVL CCCCCCCCHHHHHHH	17.94	27566939
443	Phosphorylation	EVLRRQRSLYIDLGA HHHHHHHHEEEEHHH	19.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
290	T	Phosphorylation	Kinase	IKBKB	O88351	GPS
443	S	Phosphorylation	Kinase	COT	P41279	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of M3K8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of M3K8_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of M3K8_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.