M3K11_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: M3K11_RAT
• UniProt AC: Q66HA1
• Protein Name: Mitogen-activated protein kinase kinase kinase 11
• Gene Name: Map3k11
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 850
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Location is cell cycle dependent..
• Protein Description: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle (By similarity)..
• Protein Sequence: MEPLKNLFLKSPLGSWNGSGSGGGGGSGGVRPEGSPKATAAYANPVWTALFDYEPNGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGAGDSPTFPRFRAIQLEPAESGQTWGRQSPRRLDDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSPEPEEPRRSGPTERGNSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGLSRERGESPTAPPPAQMASPCPPDLPSTPLIHLSQATPDARGPLTPAPLLLDLGVSSGQPSAKSPRREETRGRTVSPPPGISRSAPGTPGTPRSPPLGLISRPRPSPLRNRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFRGGSQDCRTQTKDVGAQAPWAPEAGP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	LKNLFLKSPLGSWNG CCCCEECCCCCCCCC	27.75	-
19	Phosphorylation	PLGSWNGSGSGGGGG CCCCCCCCCCCCCCC	26.94	28689409
21	Phosphorylation	GSWNGSGSGGGGGSG CCCCCCCCCCCCCCC	35.64	28689409
27	Phosphorylation	GSGGGGGSGGVRPEG CCCCCCCCCCCCCCC	35.33	28689409
35	Phosphorylation	GGVRPEGSPKATAAY CCCCCCCCCCCCHHH	22.89	28689409
278	Phosphorylation	LAREWHKTTQMSAAG HHHHHHHHCCCCCCH	14.90	-
282	Phosphorylation	WHKTTQMSAAGTYAW HHHHCCCCCCHHHEE	12.73	-
395	Phosphorylation	MPRDSFHSMQEGWKR CCHHHHHHHHHHHHH	21.83	-
420	Phosphorylation	AKEKELLSREEELTR HHHHHHHHHHHHHHH	50.71	30181290
504	Phosphorylation	LDFKHRITVQASPGL CCCCCEEEEEECCCC	13.41	25575281
508	Phosphorylation	HRITVQASPGLDRRR CEEEEEECCCCCCCC	11.47	27097102
525	Phosphorylation	FEVGAGDSPTFPRFR EECCCCCCCCCCCEE	25.56	29779826
527	Phosphorylation	VGAGDSPTFPRFRAI CCCCCCCCCCCEEEE	50.66	27097102
541	Phosphorylation	IQLEPAESGQTWGRQ EEEEECCCCCCCCCC	38.00	23984901
544	Phosphorylation	EPAESGQTWGRQSPR EECCCCCCCCCCCCC	33.15	23984901
549	Phosphorylation	GQTWGRQSPRRLDDS CCCCCCCCCCCCCCC	21.00	23984901
556	Phosphorylation	SPRRLDDSSNGERRA CCCCCCCCCCCCEEE	25.93	-
557	Phosphorylation	PRRLDDSSNGERRAC CCCCCCCCCCCEEEE	56.71	-
655	Phosphorylation	RGTALLASLGLGRDL HHHHHHHHCCCCCCC	23.96	-
712	Phosphorylation	PDARGPLTPAPLLLD CCCCCCCCCCCCHHH	22.12	-
728	Phosphorylation	GVSSGQPSAKSPRRE CCCCCCCCCCCCCCH	40.20	28432305
731	Phosphorylation	SGQPSAKSPRREETR CCCCCCCCCCCHHCC	24.29	28432305
741	Phosphorylation	REETRGRTVSPPPGI CHHCCCCCCCCCCCC	28.32	28432305
743	Phosphorylation	ETRGRTVSPPPGISR HCCCCCCCCCCCCCC	30.95	28432305
751	Phosphorylation	PPPGISRSAPGTPGT CCCCCCCCCCCCCCC	31.83	27097102
761	Phosphorylation	GTPGTPRSPPLGLIS CCCCCCCCCCCCCCC	31.88	27097102
773	Phosphorylation	LISRPRPSPLRNRID CCCCCCCCCCCCCCC	37.53	-
783	Phosphorylation	RNRIDPWSFVSAGPR CCCCCCCCCCCCCCC	22.59	28432305
786	Phosphorylation	IDPWSFVSAGPRPSP CCCCCCCCCCCCCCC	26.04	28432305
792	Phosphorylation	VSAGPRPSPLPSPQP CCCCCCCCCCCCCCC	40.11	28432305
796	Phosphorylation	PRPSPLPSPQPAPRR CCCCCCCCCCCCCCC	43.80	28432305
818	Phosphorylation	DSDPFWDSPPANPFR CCCCCCCCCCCCCCC	24.31	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
282	S	Phosphorylation	Kinase	MAP4K1	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
278	T	Phosphorylation	Thr-278 is likely to be the main autophosphorylation site.	-
556	S	Phosphorylation	Phosphorylation of Ser-556 and Ser-557 is induced by CDC42 (By similarity).	-
557	S	Phosphorylation	Phosphorylation of Ser-556 and Ser-557 is induced by CDC42 (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of M3K11_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRIK2_RAT	Grik2	physical	19449206
DLG4_RAT	Dlg4	physical	19449206

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.