M3K11_MOUSE - dbPTM
M3K11_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID M3K11_MOUSE
UniProt AC Q80XI6
Protein Name Mitogen-activated protein kinase kinase kinase 11
Gene Name Map3k11
Organism Mus musculus (Mouse).
Sequence Length 850
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Location is cell cycle dependent..
Protein Description Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle (By similarity)..
Protein Sequence MEPLKNLFLKSPLGSWNGSGSGGGGGTGGVRPEGSPKATAAYANPVWTALFDYEPNGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGAGDSPTFPRFRAIQLEPTESGQTWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSPEPEEPRRAGPTERGNSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGLSRERGESPTAPPPAQMPSPCPPELPSTPLIRLSQTTPDAHSSPTPGPLLLDLGVPSGQPSAKSPRREETRGRTVSPPPGISRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFRGGSQDCRTQTKDMGAQAPWAPEAGP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationLKNLFLKSPLGSWNG
CCCCEECCCCCCCCC
27.75-
35PhosphorylationGGVRPEGSPKATAAY
CCCCCCCCCCCCHHH
22.8922817900
136PhosphorylationFGKVYRGSWRGELVA
CCCCCCCCCCCEEEE
12.4723140645
278PhosphorylationLAREWHKTTQMSAAG
HHHHHHHHCCCCCCH
14.9017679097
282PhosphorylationWHKTTQMSAAGTYAW
HHHHCCCCCCHHHEE
12.7317679097
395PhosphorylationMPRDSFHSMQEGWKR
CCHHHHHHHHHHHHH
21.83-
508PhosphorylationHRITVQASPGLDRRR
CEEEEEECCCCCCCC
11.4727087446
525PhosphorylationFEVGAGDSPTFPRFR
EECCCCCCCCCCCEE
25.5625521595
527PhosphorylationVGAGDSPTFPRFRAI
CCCCCCCCCCCEEEE
50.6622324799
539PhosphorylationRAIQLEPTESGQTWG
EEEEEEECCCCCCCC
33.1523984901
541PhosphorylationIQLEPTESGQTWGRQ
EEEEECCCCCCCCCC
38.3823984901
544PhosphorylationEPTESGQTWGRQSPR
EECCCCCCCCCCCCC
33.1523984901
549PhosphorylationGQTWGRQSPRRLEDS
CCCCCCCCCCCCCCC
21.0026643407
556PhosphorylationSPRRLEDSSNGERRA
CCCCCCCCCCCCEEE
19.14-
557PhosphorylationPRRLEDSSNGERRAC
CCCCCCCCCCCEEEE
62.26-
570PhosphorylationACWAWGPSSPKPGEA
EEEEECCCCCCCCCC
56.1623684622
571PhosphorylationCWAWGPSSPKPGEAQ
EEEECCCCCCCCCCC
39.8223684622
655PhosphorylationRGTALLASLGLGRDL
HHHHHHHHCCCCCCC
23.96-
675PhosphorylationLSRERGESPTAPPPA
CCCCCCCCCCCCCCC
30.3012458207
704PhosphorylationLIRLSQTTPDAHSSP
EEEEECCCCCCCCCC
16.1328285833
709PhosphorylationQTTPDAHSSPTPGPL
CCCCCCCCCCCCCCE
39.4728285833
710PhosphorylationTTPDAHSSPTPGPLL
CCCCCCCCCCCCCEE
23.9528285833
712PhosphorylationPDAHSSPTPGPLLLD
CCCCCCCCCCCEEEE
42.71-
728PhosphorylationGVPSGQPSAKSPRRE
CCCCCCCCCCCCCCH
40.2030482847
731PhosphorylationSGQPSAKSPRREETR
CCCCCCCCCCCHHCC
24.2930482847
741PhosphorylationREETRGRTVSPPPGI
CHHCCCCCCCCCCCC
28.3228066266
743PhosphorylationETRGRTVSPPPGISR
HCCCCCCCCCCCCCC
30.9522942356
749PhosphorylationVSPPPGISRSAPGTP
CCCCCCCCCCCCCCC
26.5427600695
751PhosphorylationPPPGISRSAPGTPGT
CCCCCCCCCCCCCCC
31.8327180971
755PhosphorylationISRSAPGTPGTPRSP
CCCCCCCCCCCCCCC
19.9330635358
758PhosphorylationSAPGTPGTPRSPPLG
CCCCCCCCCCCCCCC
19.4130635358
761PhosphorylationGTPGTPRSPPLGLIS
CCCCCCCCCCCCCCC
31.8821743459
768PhosphorylationSPPLGLISRPRPSPL
CCCCCCCCCCCCCCC
41.0728066266
773PhosphorylationLISRPRPSPLRSRID
CCCCCCCCCCHHCCC
37.53-
777PhosphorylationPRPSPLRSRIDPWSF
CCCCCCHHCCCCCCC
41.07-
786PhosphorylationIDPWSFVSAGPRPSP
CCCCCCCCCCCCCCC
26.04-
792PhosphorylationVSAGPRPSPLPSPQP
CCCCCCCCCCCCCCC
40.1127180971
796PhosphorylationPRPSPLPSPQPAPRR
CCCCCCCCCCCCCCC
43.8021082442
818PhosphorylationDSDPFWDSPPANPFR
CCCCCCCCCCCCCCC
24.3126643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
282SPhosphorylationKinaseMAP4K1P70218
Uniprot
675SPhosphorylationKinaseAKT-FAMILY-GPS
675SPhosphorylationKinasePKB_GROUP-PhosphoELM

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
278TPhosphorylation

-
556SPhosphorylation

-
557SPhosphorylation

-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of M3K11_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of M3K11_MOUSE !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of M3K11_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-743, AND MASSSPECTROMETRY.

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