UniProt ID | M3K11_MOUSE | |
---|---|---|
UniProt AC | Q80XI6 | |
Protein Name | Mitogen-activated protein kinase kinase kinase 11 | |
Gene Name | Map3k11 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 850 | |
Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Location is cell cycle dependent.. | |
Protein Description | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle (By similarity).. | |
Protein Sequence | MEPLKNLFLKSPLGSWNGSGSGGGGGTGGVRPEGSPKATAAYANPVWTALFDYEPNGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGAGDSPTFPRFRAIQLEPTESGQTWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSPEPEEPRRAGPTERGNSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGLSRERGESPTAPPPAQMPSPCPPELPSTPLIRLSQTTPDAHSSPTPGPLLLDLGVPSGQPSAKSPRREETRGRTVSPPPGISRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFRGGSQDCRTQTKDMGAQAPWAPEAGP | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
|
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
11 | Phosphorylation | LKNLFLKSPLGSWNG CCCCEECCCCCCCCC | 27.75 | - | |
35 | Phosphorylation | GGVRPEGSPKATAAY CCCCCCCCCCCCHHH | 22.89 | 22817900 | |
136 | Phosphorylation | FGKVYRGSWRGELVA CCCCCCCCCCCEEEE | 12.47 | 23140645 | |
278 | Phosphorylation | LAREWHKTTQMSAAG HHHHHHHHCCCCCCH | 14.90 | 17679097 | |
282 | Phosphorylation | WHKTTQMSAAGTYAW HHHHCCCCCCHHHEE | 12.73 | 17679097 | |
395 | Phosphorylation | MPRDSFHSMQEGWKR CCHHHHHHHHHHHHH | 21.83 | - | |
508 | Phosphorylation | HRITVQASPGLDRRR CEEEEEECCCCCCCC | 11.47 | 27087446 | |
525 | Phosphorylation | FEVGAGDSPTFPRFR EECCCCCCCCCCCEE | 25.56 | 25521595 | |
527 | Phosphorylation | VGAGDSPTFPRFRAI CCCCCCCCCCCEEEE | 50.66 | 22324799 | |
539 | Phosphorylation | RAIQLEPTESGQTWG EEEEEEECCCCCCCC | 33.15 | 23984901 | |
541 | Phosphorylation | IQLEPTESGQTWGRQ EEEEECCCCCCCCCC | 38.38 | 23984901 | |
544 | Phosphorylation | EPTESGQTWGRQSPR EECCCCCCCCCCCCC | 33.15 | 23984901 | |
549 | Phosphorylation | GQTWGRQSPRRLEDS CCCCCCCCCCCCCCC | 21.00 | 26643407 | |
556 | Phosphorylation | SPRRLEDSSNGERRA CCCCCCCCCCCCEEE | 19.14 | - | |
557 | Phosphorylation | PRRLEDSSNGERRAC CCCCCCCCCCCEEEE | 62.26 | - | |
570 | Phosphorylation | ACWAWGPSSPKPGEA EEEEECCCCCCCCCC | 56.16 | 23684622 | |
571 | Phosphorylation | CWAWGPSSPKPGEAQ EEEECCCCCCCCCCC | 39.82 | 23684622 | |
655 | Phosphorylation | RGTALLASLGLGRDL HHHHHHHHCCCCCCC | 23.96 | - | |
675 | Phosphorylation | LSRERGESPTAPPPA CCCCCCCCCCCCCCC | 30.30 | 12458207 | |
704 | Phosphorylation | LIRLSQTTPDAHSSP EEEEECCCCCCCCCC | 16.13 | 28285833 | |
709 | Phosphorylation | QTTPDAHSSPTPGPL CCCCCCCCCCCCCCE | 39.47 | 28285833 | |
710 | Phosphorylation | TTPDAHSSPTPGPLL CCCCCCCCCCCCCEE | 23.95 | 28285833 | |
712 | Phosphorylation | PDAHSSPTPGPLLLD CCCCCCCCCCCEEEE | 42.71 | - | |
728 | Phosphorylation | GVPSGQPSAKSPRRE CCCCCCCCCCCCCCH | 40.20 | 30482847 | |
731 | Phosphorylation | SGQPSAKSPRREETR CCCCCCCCCCCHHCC | 24.29 | 30482847 | |
741 | Phosphorylation | REETRGRTVSPPPGI CHHCCCCCCCCCCCC | 28.32 | 28066266 | |
743 | Phosphorylation | ETRGRTVSPPPGISR HCCCCCCCCCCCCCC | 30.95 | 22942356 | |
749 | Phosphorylation | VSPPPGISRSAPGTP CCCCCCCCCCCCCCC | 26.54 | 27600695 | |
751 | Phosphorylation | PPPGISRSAPGTPGT CCCCCCCCCCCCCCC | 31.83 | 27180971 | |
755 | Phosphorylation | ISRSAPGTPGTPRSP CCCCCCCCCCCCCCC | 19.93 | 30635358 | |
758 | Phosphorylation | SAPGTPGTPRSPPLG CCCCCCCCCCCCCCC | 19.41 | 30635358 | |
761 | Phosphorylation | GTPGTPRSPPLGLIS CCCCCCCCCCCCCCC | 31.88 | 21743459 | |
768 | Phosphorylation | SPPLGLISRPRPSPL CCCCCCCCCCCCCCC | 41.07 | 28066266 | |
773 | Phosphorylation | LISRPRPSPLRSRID CCCCCCCCCCHHCCC | 37.53 | - | |
777 | Phosphorylation | PRPSPLRSRIDPWSF CCCCCCHHCCCCCCC | 41.07 | - | |
786 | Phosphorylation | IDPWSFVSAGPRPSP CCCCCCCCCCCCCCC | 26.04 | - | |
792 | Phosphorylation | VSAGPRPSPLPSPQP CCCCCCCCCCCCCCC | 40.11 | 27180971 | |
796 | Phosphorylation | PRPSPLPSPQPAPRR CCCCCCCCCCCCCCC | 43.80 | 21082442 | |
818 | Phosphorylation | DSDPFWDSPPANPFR CCCCCCCCCCCCCCC | 24.31 | 26643407 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
282 | S | Phosphorylation | Kinase | MAP4K1 | P70218 | Uniprot |
675 | S | Phosphorylation | Kinase | AKT-FAMILY | - | GPS |
675 | S | Phosphorylation | Kinase | PKB_GROUP | - | PhosphoELM |
Modified Location | Modified Residue | Modification | Function | Reference |
---|---|---|---|---|
278 | T | Phosphorylation |
| - |
556 | S | Phosphorylation |
| - |
557 | S | Phosphorylation |
| - |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of M3K11_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of M3K11_MOUSE !! |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-743, AND MASSSPECTROMETRY. |