M3K11_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: M3K11_MOUSE
• UniProt AC: Q80XI6
• Protein Name: Mitogen-activated protein kinase kinase kinase 11
• Gene Name: Map3k11
• Organism: Mus musculus (Mouse).
• Sequence Length: 850
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Location is cell cycle dependent..
• Protein Description: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle (By similarity)..
• Protein Sequence: MEPLKNLFLKSPLGSWNGSGSGGGGGTGGVRPEGSPKATAAYANPVWTALFDYEPNGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGAGDSPTFPRFRAIQLEPTESGQTWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSPEPEEPRRAGPTERGNSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGLSRERGESPTAPPPAQMPSPCPPELPSTPLIRLSQTTPDAHSSPTPGPLLLDLGVPSGQPSAKSPRREETRGRTVSPPPGISRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFRGGSQDCRTQTKDMGAQAPWAPEAGP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	LKNLFLKSPLGSWNG CCCCEECCCCCCCCC	27.75	-
35	Phosphorylation	GGVRPEGSPKATAAY CCCCCCCCCCCCHHH	22.89	22817900
136	Phosphorylation	FGKVYRGSWRGELVA CCCCCCCCCCCEEEE	12.47	23140645
278	Phosphorylation	LAREWHKTTQMSAAG HHHHHHHHCCCCCCH	14.90	17679097
282	Phosphorylation	WHKTTQMSAAGTYAW HHHHCCCCCCHHHEE	12.73	17679097
395	Phosphorylation	MPRDSFHSMQEGWKR CCHHHHHHHHHHHHH	21.83	-
508	Phosphorylation	HRITVQASPGLDRRR CEEEEEECCCCCCCC	11.47	27087446
525	Phosphorylation	FEVGAGDSPTFPRFR EECCCCCCCCCCCEE	25.56	25521595
527	Phosphorylation	VGAGDSPTFPRFRAI CCCCCCCCCCCEEEE	50.66	22324799
539	Phosphorylation	RAIQLEPTESGQTWG EEEEEEECCCCCCCC	33.15	23984901
541	Phosphorylation	IQLEPTESGQTWGRQ EEEEECCCCCCCCCC	38.38	23984901
544	Phosphorylation	EPTESGQTWGRQSPR EECCCCCCCCCCCCC	33.15	23984901
549	Phosphorylation	GQTWGRQSPRRLEDS CCCCCCCCCCCCCCC	21.00	26643407
556	Phosphorylation	SPRRLEDSSNGERRA CCCCCCCCCCCCEEE	19.14	-
557	Phosphorylation	PRRLEDSSNGERRAC CCCCCCCCCCCEEEE	62.26	-
570	Phosphorylation	ACWAWGPSSPKPGEA EEEEECCCCCCCCCC	56.16	23684622
571	Phosphorylation	CWAWGPSSPKPGEAQ EEEECCCCCCCCCCC	39.82	23684622
655	Phosphorylation	RGTALLASLGLGRDL HHHHHHHHCCCCCCC	23.96	-
675	Phosphorylation	LSRERGESPTAPPPA CCCCCCCCCCCCCCC	30.30	12458207
704	Phosphorylation	LIRLSQTTPDAHSSP EEEEECCCCCCCCCC	16.13	28285833
709	Phosphorylation	QTTPDAHSSPTPGPL CCCCCCCCCCCCCCE	39.47	28285833
710	Phosphorylation	TTPDAHSSPTPGPLL CCCCCCCCCCCCCEE	23.95	28285833
712	Phosphorylation	PDAHSSPTPGPLLLD CCCCCCCCCCCEEEE	42.71	-
728	Phosphorylation	GVPSGQPSAKSPRRE CCCCCCCCCCCCCCH	40.20	30482847
731	Phosphorylation	SGQPSAKSPRREETR CCCCCCCCCCCHHCC	24.29	30482847
741	Phosphorylation	REETRGRTVSPPPGI CHHCCCCCCCCCCCC	28.32	28066266
743	Phosphorylation	ETRGRTVSPPPGISR HCCCCCCCCCCCCCC	30.95	22942356
749	Phosphorylation	VSPPPGISRSAPGTP CCCCCCCCCCCCCCC	26.54	27600695
751	Phosphorylation	PPPGISRSAPGTPGT CCCCCCCCCCCCCCC	31.83	27180971
755	Phosphorylation	ISRSAPGTPGTPRSP CCCCCCCCCCCCCCC	19.93	30635358
758	Phosphorylation	SAPGTPGTPRSPPLG CCCCCCCCCCCCCCC	19.41	30635358
761	Phosphorylation	GTPGTPRSPPLGLIS CCCCCCCCCCCCCCC	31.88	21743459
768	Phosphorylation	SPPLGLISRPRPSPL CCCCCCCCCCCCCCC	41.07	28066266
773	Phosphorylation	LISRPRPSPLRSRID CCCCCCCCCCHHCCC	37.53	-
777	Phosphorylation	PRPSPLRSRIDPWSF CCCCCCHHCCCCCCC	41.07	-
786	Phosphorylation	IDPWSFVSAGPRPSP CCCCCCCCCCCCCCC	26.04	-
792	Phosphorylation	VSAGPRPSPLPSPQP CCCCCCCCCCCCCCC	40.11	27180971
796	Phosphorylation	PRPSPLPSPQPAPRR CCCCCCCCCCCCCCC	43.80	21082442
818	Phosphorylation	DSDPFWDSPPANPFR CCCCCCCCCCCCCCC	24.31	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
282	S	Phosphorylation	Kinase	MAP4K1	P70218	Uniprot
675	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
675	S	Phosphorylation	Kinase	PKB_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
278	T	Phosphorylation	Thr-278 is likely to be the main autophosphorylation site.	-
556	S	Phosphorylation	Phosphorylation of Ser-556 and Ser-557 is induced by CDC42 (By similarity).	-
557	S	Phosphorylation	Phosphorylation of Ser-556 and Ser-557 is induced by CDC42 (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of M3K11_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of M3K11_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-743, AND MASSSPECTROMETRY.
PubMed: 19144319