M3K10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: M3K10_MOUSE
• UniProt AC: Q66L42
• Protein Name: Mitogen-activated protein kinase kinase kinase 10
• Gene Name: Map3k10
• Organism: Mus musculus (Mouse).
• Sequence Length: 940
• Protein Description: Activates the JUN N-terminal pathway..
• Protein Sequence: MEEEEGAAAREWGATPAGPVWTAVFDYEAVGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPAAPAAPSDLQLPQEIPFHELQLEEIIGVGGFGKVYRAVWRGEEVAVKAARLDPERDPAVTAEQVRQEARLFGALQHPNIIALRGACLSPPNLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMSQLSQEKPRVRKRKGNFKRSRLLKLREGSSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPMDCGGSSGSGTWSRSGPPKKEELVGGKKKGRTWGPSSTLQKERAGGEERLKALGEGSKQWSSSAPNLGKSPKHTPMAPGFASLNEMEEFAEADEGNNVPPSPYSTPSYLKVPLPAEPSPCVQAPWEPPAVTPSRPGHGARRRCDLALLSCATLLSAVGLGADVAEARAGDGEEQRRWLDSLFFPRPGRFPRGLSPTGRPGGRREDTAPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPLAPSPSTNPLVDVELESFKKDPRQSLTPTHVTAAHAVSRGHRRTPSDGALRQREPLELTNHGPRDPLDFPRLPDPQALFPTRRRPLEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLSISPPSRPDTPESPGPPSVQPTLLDMDMEGQSQDNTVPLCGVYGSH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
225	Phosphorylation	IIHRDLKSINILILE EECCCHHHCCEEEHH	28.32	-
258	Phosphorylation	LAREWHKTTKMSAAG HHHHHHHCCCCCCCC	20.82	29899451
259	Phosphorylation	AREWHKTTKMSAAGT HHHHHHCCCCCCCCH	29.56	29899451
262	Phosphorylation	WHKTTKMSAAGTYAW HHHCCCCCCCCHHHH	19.27	21183079
266	Phosphorylation	TKMSAAGTYAWMAPE CCCCCCCHHHHHCHH	12.82	29899451
267	Phosphorylation	KMSAAGTYAWMAPEV CCCCCCHHHHHCHHH	9.43	20469934
446	Phosphorylation	HLLMSQLSQEKPRVR HHHHHHHHHCCCCHH	28.76	29899451
472	Phosphorylation	LKLREGSSHISLPSG HHHCCCCCCCCCCCC	35.38	29899451
485	Phosphorylation	SGFEHKITVQASPTL CCCCEEEEEEECCCC	16.03	29899451
489	Phosphorylation	HKITVQASPTLDKRK EEEEEEECCCCCCCC	11.00	29899451
491	Phosphorylation	ITVQASPTLDKRKGS EEEEECCCCCCCCCC	45.13	22324799
498	Phosphorylation	TLDKRKGSDGASPPA CCCCCCCCCCCCCCC	35.59	27180971
502	Phosphorylation	RKGSDGASPPASPSI CCCCCCCCCCCCCCH	36.62	25521595
506	Phosphorylation	DGASPPASPSIIPRL CCCCCCCCCCHHHHH	25.59	22345495
508	Phosphorylation	ASPPASPSIIPRLRA CCCCCCCCHHHHHCE	30.56	19060867
519	Phosphorylation	RLRAIRLTPMDCGGS HHCEEEEEECCCCCC	13.50	-
519	O-linked_Glycosylation	RLRAIRLTPMDCGGS HHCEEEEEECCCCCC	13.50	30016717
531	O-linked_Glycosylation	GGSSGSGTWSRSGPP CCCCCCCCCCCCCCC	23.20	30016717
533	Phosphorylation	SSGSGTWSRSGPPKK CCCCCCCCCCCCCCH	19.19	-
552	Phosphorylation	GGKKKGRTWGPSSTL CCCCCCCCCCCCHHH	43.36	19060867
557	Phosphorylation	GRTWGPSSTLQKERA CCCCCCCHHHHHHHC	35.95	29899451
577	Phosphorylation	LKALGEGSKQWSSSA HHHHHCCCCCCCCCC	19.85	-
581	Phosphorylation	GEGSKQWSSSAPNLG HCCCCCCCCCCCCCC	16.36	29899451
582	Phosphorylation	EGSKQWSSSAPNLGK CCCCCCCCCCCCCCC	27.79	29899451
583	Phosphorylation	GSKQWSSSAPNLGKS CCCCCCCCCCCCCCC	42.08	20415495
590	Phosphorylation	SAPNLGKSPKHTPMA CCCCCCCCCCCCCCC	37.06	20415495
716	Phosphorylation	FPRGLSPTGRPGGRR CCCCCCCCCCCCCCC	42.31	29899451
737	Phosphorylation	LGLAPSATLVSLSSV CCCCCCCEEEECCCC	31.84	23608596
740	Phosphorylation	APSATLVSLSSVSDC CCCCEEEECCCCCCC	26.16	23608596
745	Phosphorylation	LVSLSSVSDCNSTRS EEECCCCCCCCHHHH	38.09	23608596
749	Phosphorylation	SSVSDCNSTRSLLRS CCCCCCCHHHHHHHC	31.37	23608596
752	Phosphorylation	SDCNSTRSLLRSDSD CCCCHHHHHHHCCCC	31.66	29899451
756	Phosphorylation	STRSLLRSDSDEAAP HHHHHHHCCCCCCCC	41.24	29899451
758	Phosphorylation	RSLLRSDSDEAAPAA HHHHHCCCCCCCCCC	38.30	29899451
767	Phosphorylation	EAAPAAPSPPPSPLA CCCCCCCCCCCCCCC	45.36	22807455
797	Phosphorylation	FKKDPRQSLTPTHVT HCCCCCCCCCCCCHH	35.17	29899451
818	Phosphorylation	RGHRRTPSDGALRQR CCCCCCCCCCCCCCC	48.33	22324799
843	Methylation	RDPLDFPRLPDPQAL CCCCCCCCCCCHHHC	59.87	24129315

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
262	S	Phosphorylation	Kinase	MAP4K1	P70218	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of M3K10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of M3K10_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of M3K10_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.