LZTS1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LZTS1_MOUSE
• UniProt AC: P60853
• Protein Name: Leucine zipper putative tumor suppressor 1
• Gene Name: Lzts1
• Organism: Mus musculus (Mouse).
• Sequence Length: 599
• Subcellular Localization: Cytoplasm. Cell membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Associated with the plasma membrane and with microtubules. Detected in dendritic spines, esp
• Protein Description: Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as tumor suppressor (By similarity)..
• Protein Sequence: MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGRGKSSSKMGKSEDFFYIKVSQKARGSHRPDYTALSSGDIGGQTGVDFDPATPPKLMPFSNQLEMSSDKGAVRPTAFKPVLPRSGAILHSSPESTSHQLHPMPPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTTSSYQLDPLVTPVGPTSRFGGSAHNITQGIILQDSNMMSLKALSFSDGGSKLAHPGKADKGASCVRSPLSTDECTIQELEQKLLQRETALQKLQRSFDEKEFASGQTFEERPRRTRDELECLEPKSKLKPPSQKSQRTQQVLQLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTNFAPALEETQWEVCQKSGEISLLKQQLKESQLEVNTKASEILSLKAQLKDTRGKLDGMELKTQDLESALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELMELRAQAALHPAPLGPPGVGLTFSEDIPALQRELDRLRAELKEERQGHDQMSSGFQHERLVWKEEKEKVIQYQRQLQQSYLAMYQRNQRLEKALQQLARGDGPGEPFEIDLEGADIPYEDIIATEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGSVSSLIS ------CCCHHHHHC	36.43	-
21	Phosphorylation	HSKHCRASQYKLRKS CCHHHCHHHHHHHHC	18.07	-
28	Phosphorylation	SQYKLRKSSHLKKLN HHHHHHHCHHHHHHC	19.29	29899451
29	Phosphorylation	QYKLRKSSHLKKLNR HHHHHHCHHHHHHCC	35.55	29899451
38	Phosphorylation	LKKLNRYSDGLLRFG HHHHCCCCCCCCCCC	23.20	29899451
50	Phosphorylation	RFGFSQDSGRGKSSS CCCCCCCCCCCCCCC	23.81	22324799
71	Phosphorylation	DFFYIKVSQKARGSH CEEEEEECHHCCCCC	22.44	26643407
102	Phosphorylation	GVDFDPATPPKLMPF CCCCCCCCCCCCCCC	45.58	25521595
110	Phosphorylation	PPKLMPFSNQLEMSS CCCCCCCCCCEECCC	20.14	29119230
116	Phosphorylation	FSNQLEMSSDKGAVR CCCCEECCCCCCCCC	26.47	29119230
117	Phosphorylation	SNQLEMSSDKGAVRP CCCEECCCCCCCCCC	41.87	29119230
125	Phosphorylation	DKGAVRPTAFKPVLP CCCCCCCCCCCCCCC	33.87	29119230
209	Phosphorylation	PTSRFGGSAHNITQG CCCCCCCCCCCCCCE	27.08	26643407
214	Phosphorylation	GGSAHNITQGIILQD CCCCCCCCCEEEEEC	26.51	26643407
231	Phosphorylation	MMSLKALSFSDGGSK CCCEEEEEECCCCCC	27.80	22324799
233	Phosphorylation	SLKALSFSDGGSKLA CEEEEEECCCCCCCC	31.78	22324799
237	Phosphorylation	LSFSDGGSKLAHPGK EEECCCCCCCCCCCC	29.99	28066266
250	Phosphorylation	GKADKGASCVRSPLS CCCCCCCCCCCCCCC	23.08	29899451
254	Phosphorylation	KGASCVRSPLSTDEC CCCCCCCCCCCCCCC	15.14	29899451
257	Phosphorylation	SCVRSPLSTDECTIQ CCCCCCCCCCCCHHH	36.88	29899451
258	Phosphorylation	CVRSPLSTDECTIQE CCCCCCCCCCCHHHH	43.42	29899451
283	Phosphorylation	ALQKLQRSFDEKEFA HHHHHHHHCCHHHHH	24.88	22324799
319	Phosphorylation	KSKLKPPSQKSQRTQ HHHCCCCCHHHHHHH	59.78	29899451
541	Ubiquitination	VWKEEKEKVIQYQRQ HCHHHHHHHHHHHHH	56.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LZTS1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LZTS1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LZTS1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LZTS1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.