LYS2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LYS2_SCHPO
• UniProt AC: P40976
• Protein Name: L-2-aminoadipate reductase
• Gene Name: lys1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1419
• Subcellular Localization: Cytoplasm .
• Protein Description: Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate..
• Protein Sequence: MSQTAPSDTEYNQRLERWSERLKSQTISHLPTDYSRPVPSRLVEAVFERTLPEDAKTALIKVYVAAQAKGILVTPFNILLTIFIILVSRMTGDEDISIGTSSENAIPFVLRTFIQPSDSFLDLLAKVCDLEKEGSSDAVDFSDLINFLNAKLSKKDDPRKTLVHLRFYNAPDAPSENFLSTTGLDVDLTVLVSVKKPSDQLTSLRSQFTFPDLQLKLIYNQLLFSESRVNIVADQLLKLVVSASKDVTGPIGALDLMTPTQMNVLPDPTVDLDWSGYRGAIQDIFASNAAKFPDRECIVVTPSVTIDAPVTSYTYRQIDESSNILAHHLVKNGIERGDVVMVYAYRGVDLVVAVMGVLKAGATFSVIDPAYPPARQIIYLSVAKPRALVVLEDAGVLSPTVVEYVEKSLELKTYVPALKLAKDGSLTGGSVSKGADDILQHVLHLKSEQTGVVVGPDSTPTLSFTSGSEGIPKGVKGRHFSLAYYFDWMAQEFNLSESDRFTMLSGIAHDPIQRDIFTPLFLGASLIVPTAEDIGTPGQLAQWANKYKVTVTHLTPAMGQLLAAQADEPIPSLHHAFFVGDILTKRDCLRLQVLANNVNVVNMYGTTETQRSVSYFVVPARSQDQTFLESQKDVIPAGRGMKNVQLLVINRFDTNKICGIGEVGEIYLRAGGLAEGYLGNDELTSKKFLKSWFADPSKFVDRTPENAPWKPYWFGIRDRMYRSGDLGRYLPTGNVECSGRADDQIKIRGFRIELGEINTHLSRHPNVRENITLVRRDKDEEPTLVAYIVPQGLNKDDFDSATESEDIVVNGLKKYRKLIHDIREYLKTKLPSYAIPSVIVPLHKMPLNPNGKIDKPALPFPDTSQLAAASRSHSKHGVDETLTATERDIRDIWLRIIPHATDVNKKASFFDIGGHSILATRLIFELRKKFAVNVPLGLVFSEPTIEGLAKEIERMKSGEMISVMDIGKEETREPEIEYGKDALDLVDLIPKEFPTSKDLGIDEPKTVFLTGANGYLGVFILRDLMTRSSNLKVIALVRASSEEHGLKRLKDSCTAYGVWDESWAQKISVVNGDLALENWGIEERKWNKLTEVVDYVIHNGALVHWVYPYSKLRGPNVMGTITALKLCSLGKGKSLSFVSSTSTVDTEYYVNLSNEITSKGGNGIPESDPLQGSSKDLHTGYGQSKWVSEYLVRQAGLRGLRGVVVRPGYILGDSKSGAINTDDFLVRMVKGCIELGLYPNINNTVNMVPADHVARVVTASAFHPEQGVIVAHVTSHPRLRFNQFLGTLSTFGFNTKLSEYVNWRIALERFVINESHDSALYPLLHFVLDNLPANTKAPELDDTNTREILKRDASWTNVDVSNGAAILEHEMGLYLSYLVAIGFLPKPTLEGKKLPEVKINEATLEKLASAGGRGGAPTH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSQTAPSDT ------CCCCCCCCH	47.76	29996109
4	Phosphorylation	----MSQTAPSDTEY ----CCCCCCCCHHH	50.23	29996109
117	Phosphorylation	LRTFIQPSDSFLDLL HHHHCCCCHHHHHHH	29.52	25720772
206	Phosphorylation	DQLTSLRSQFTFPDL HHHHHHHHHCCCCHH	34.63	25720772
287	Phosphorylation	AIQDIFASNAAKFPD HHHHHHHHCCCCCCC	19.09	28889911
612	Phosphorylation	GTTETQRSVSYFVVP CCCCCCCEEEEEEEE	12.95	25720772
614	Phosphorylation	TETQRSVSYFVVPAR CCCCCEEEEEEEECC	17.69	25720772
622	Phosphorylation	YFVVPARSQDQTFLE EEEEECCCCCCHHHH	39.97	25720772
800	Phosphorylation	LNKDDFDSATESEDI CCHHHCCCCCCCCHH	36.76	28889911
802	Phosphorylation	KDDFDSATESEDIVV HHHCCCCCCCCHHHH	43.95	29996109
804	Phosphorylation	DFDSATESEDIVVNG HCCCCCCCCHHHHHH	35.89	29996109
870	Phosphorylation	TSQLAAASRSHSKHG HHHHHHHHHCHHCCC	29.59	25720772
916	O-(pantetheine 4'-phosphoryl)serine	FFDIGGHSILATRLI CEECCCHHHHHHHHH	23.67	-
916	Phosphorylation	FFDIGGHSILATRLI CEECCCHHHHHHHHH	23.67	25720772
962	Phosphorylation	MKSGEMISVMDIGKE HHCCCEEEEEECCCC	15.30	28889911
1216	Phosphorylation	YILGDSKSGAINTDD EEECCCCCCCCCCHH	37.09	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LYS2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LYS2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LYS2_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of LYS2_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.