LYAG_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LYAG_RAT
• UniProt AC: Q6P7A9
• Protein Name: Lysosomal alpha-glucosidase
• Gene Name: Gaa
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 953
• Subcellular Localization: Lysosome . Lysosome membrane .
• Protein Description: Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans..
• Protein Sequence: MNIRKPLCSNSVVGACTLVSLTTAVILGHLMLRELMLLPQDLHESSSGLWKTYRPHHQESYEPAPLHIQEHAEQLRAVPTQCDVTPNSRFDCAPDKGITQEQCEARGCCWVPAGQVLNGPVMGQPWCFFPPSYPSYRLENLSSTESGYTATLTRTSPTFFPKDVLTLQLEVLMETDSRLHFMIKDPTSKRYEVPLETPRVLSQAPSPLYSVEFSEEPFGVIVRRKLGGRVLLNTTVAPLFFADQFLQLSTSLPSQHIAGLGEHLSPLMLSTEWTRITLWNRDVAPSQGVNLYGSHPFYLALEDGGLAHGVFLLNSNAMDVVLQPSPALTWRSTGGILDVYVFLGPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAIVRQVVENMTRTHFPLDVQWNDLDYMDARRDFTFNQDGFADFPDMVHELHQGGRRYMMIVDPAISSSGPAGSYRPYDEGLRRGVFITNETGQPLIGKVWPGSTAFPDFTNPETLDWWQDMVSEFHAQVPFDGMWIDMNEPSNFIRGSQQGCPDNELENPPYVPGVVGGALQAATICASSHQFLSTHYNLHNLYGLTEAIASSRALVKTRGTRPFVISRSTFAGHGRYAGHWTGDVWSSWEHLAYSVPEILQFNLLGVPLVGADICGFQGNTTEELCVRWTQLGAFYPFMRNHNDLNSLPQEPYRFSETAQQAMRKAFTLRYALLPYLYTLFHGAHVKGDTVARPLFLEFPEDPSTWSVDRQLLWGPALLITPVLEPGKTDVTGYFPKGMWYNLQMVPVETLGSLPSSSPASSFRSIVHSKGQWLTLEAPLDTINVHLRAGYIIPLQGPSLTTTESRKQPMALAVALTESGEASGELFWDDGESLGVLERGAYTLVTFSAKNNTIVNKLVHVTKEGGELQLREVTILGVTTAPTQVLSNGISVSNFTYSPDDKSLSIPVSLLMGERFQIDWS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
140	N-linked_Glycosylation	YPSYRLENLSSTESG CCCEEECCCCCCCCC	50.22	-
233	N-linked_Glycosylation	LGGRVLLNTTVAPLF CCCEEEEECCCHHHH	29.55	-
390	N-linked_Glycosylation	IVRQVVENMTRTHFP HHHHHHHHCCCCCCC	26.05	-
470	N-linked_Glycosylation	RRGVFITNETGQPLI CCCEEEECCCCCCCC	39.76	-
590	Phosphorylation	SSRALVKTRGTRPFV HCCCHHHCCCCCCEE	27.18	22673903
652	N-linked_Glycosylation	DICGFQGNTTEELCV EECCCCCCCHHHHHH	32.80	-
883	N-linked_Glycosylation	LVTFSAKNNTIVNKL EEEEECCCCCEEEEE	51.06	-
926	N-linked_Glycosylation	SNGISVSNFTYSPDD CCCCEEECCEECCCC	30.99	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LYAG_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LYAG_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LYAG_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of LYAG_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.