dbPTM

LY96_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LY96_HUMAN
UniProt AC	Q9Y6Y9
Protein Name	Lymphocyte antigen 96
Gene Name	LY96
Organism	Homo sapiens (Human).
Sequence Length	160
Subcellular Localization	Secreted, extracellular space . Secreted . Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581).
Protein Description	Binds bacterial lipopolysaccharide (LPS). [PubMed: 17803912]
Protein Sequence	MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKRSKGLLHIFYIPRRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFSFKGIKFSKGKYKCVVEAISGSPEEMLFCLEFVILHQPNSN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	FTEAQKQYWVCNSSD HHHHHHHEEEECCCC	13.57	-
26	N-linked_Glycosylation	QKQYWVCNSSDASIS HHHEEEECCCCCEEE	34.62	17569869
42	Phosphorylation	TYCDKMQYPISINVN EECCCCCCEEEEEEC	10.07	25002506
45	Phosphorylation	DKMQYPISINVNPCI CCCCCEEEEEECCCE	12.01	25002506
114	N-linked_Glycosylation	ALKGETVNTTISFSF HHCCCEECEEEEEEE	38.64	17569869
120	Phosphorylation	VNTTISFSFKGIKFS ECEEEEEEECCCEEC	21.18	24719451
131	Phosphorylation	IKFSKGKYKCVVEAI CEECCCEEEEEEEEC	20.49	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
22	Y	Phosphorylation	Kinase	LYN	P07948	PSP
131	Y	Phosphorylation	Kinase	LYN	P07948	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LY96_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LY96_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
TLR4_HUMAN	TLR4	physical	11976338

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LY96_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Crystal structures of human MD-2 and its complex with antiendotoxiclipid IVa."; Ohto U., Fukase K., Miyake K., Satow Y.; Science 316:1632-1634(2007). Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 17-160 IN COMPLEX WITH LIPIDIV-A, DISULFIDE BONDS, AND GLYCOSYLATION AT ASN-26 AND ASN-114.	17569869 [Abstract]