LY6H_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LY6H_HUMAN
• UniProt AC: O94772
• Protein Name: Lymphocyte antigen 6H
• Gene Name: LY6H
• Organism: Homo sapiens (Human).
• Sequence Length: 140
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor.
• Protein Description: Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons..
• Protein Sequence: MLPAAMKGLGLALLAVLLCSAPAHGLWCQDCTLTTNSSHCTPKQCQPSDTVCASVRITDPSSSRKDHSVNKMCASSCDFVKRHFFSDYLMGFINSGILKVDVDCCEKDLCNGAAGAGHSPWALAGGLLLSLGPALLWAGP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	N-linked_Glycosylation	QDCTLTTNSSHCTPK CCCEEECCCCCCCCC	35.96	UniProtKB CARBOHYD
68	Phosphorylation	SSSRKDHSVNKMCAS CCCCCCCCHHHHHHH	37.20	28348404
88	Phosphorylation	KRHFFSDYLMGFINS HHHHCHHHHHHHHHC	9.44	-
95	Phosphorylation	YLMGFINSGILKVDV HHHHHHHCCCEEEEH	23.53	-
115	GPI-anchor	DLCNGAAGAGHSPWA CCCCCCCCCCCCHHH	31.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LY6H_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LY6H_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LY6H_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of LY6H_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.