dbPTM

LY6E_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LY6E_HUMAN
UniProt AC	Q16553
Protein Name	Lymphocyte antigen 6E
Gene Name	LY6E
Organism	Homo sapiens (Human).
Sequence Length	131
Subcellular Localization	Cell membrane Lipid-anchor, GPI-anchor.
Protein Description	Involved in T-cell development. Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response..
Protein Sequence	MKIFLPVLLAALLGVERASSLMCFSCLNQKSNLYCLKPTICSDQDNYCVTVSASAGIGNLVTFGHSLSKTCSPACPIPEGVNVGVASMGISCCQSFLCNFSAADGGLRASVTLLGAGLLLSLLPALLRFGP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Ubiquitination	KSNLYCLKPTICSDQ CCCEEEECCEEECCC	36.23	21963094
50	O-linked_Glycosylation	DQDNYCVTVSASAGI CCCCEEEEEEECCCC	12.75	OGP
52	O-linked_Glycosylation	DNYCVTVSASAGIGN CCEEEEEEECCCCCC	13.72	OGP
54	O-linked_Glycosylation	YCVTVSASAGIGNLV EEEEEEECCCCCCCC	21.37	OGP
62	O-linked_Glycosylation	AGIGNLVTFGHSLSK CCCCCCCCCCCCCCC	27.37	OGP
99	N-linked_Glycosylation	CCQSFLCNFSAADGG HHHHHHHCCCCCCCC	35.73	UniProtKB CARBOHYD
101	GPI-anchor	QSFLCNFSAADGGLR HHHHHCCCCCCCCHH	14.46	-
121	Phosphorylation	LGAGLLLSLLPALLR HHHHHHHHHHHHHHH	28.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LY6E_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LY6E_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LY6E_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CD3Z_HUMAN	CD247	physical	9575182

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LY6E_HUMAN

Related Literatures of Post-Translational Modification