LTOR1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LTOR1_RAT
• UniProt AC: Q6P791
• Protein Name: Ragulator complex protein LAMTOR1
• Gene Name: Lamtor1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 161
• Subcellular Localization: Late endosome membrane; Lipid-anchor; Cytoplasmic side. Lysosome membrane; Lipid-anchor; Cytoplasmic side. Cell membrane ; Lipid-anchor .
• Protein Description: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation (By similarity)..
• Protein Sequence: MGCCYSSENEDSDQDQEERKLLLDPSNTPTKALNGAEPSYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGCCYSSEN ------CCCCCCCCC	15.37	-
20	Ubiquitination	DQDQEERKLLLDPSN CCCHHHHHHHCCCCC	46.93	-
26	Phosphorylation	RKLLLDPSNTPTKAL HHHHCCCCCCCCHHH	53.66	23712012
28	Phosphorylation	LLLDPSNTPTKALNG HHCCCCCCCCHHHCC	36.35	23712012
30	Phosphorylation	LDPSNTPTKALNGAE CCCCCCCCHHHCCCC	27.23	27097102
31	Ubiquitination	DPSNTPTKALNGAEP CCCCCCCHHHCCCCC	52.67	-
39	Phosphorylation	ALNGAEPSYHSLPSA HHCCCCCCCCCCCCC	27.30	29779826
40	Phosphorylation	LNGAEPSYHSLPSAR HCCCCCCCCCCCCCC	13.22	22276854
42	Phosphorylation	GAEPSYHSLPSARTD CCCCCCCCCCCCCCH	33.47	22673903
45	Phosphorylation	PSYHSLPSARTDEQA CCCCCCCCCCCHHHH	35.36	22673903
48	Phosphorylation	HSLPSARTDEQALLS CCCCCCCCHHHHHHH	43.54	30181290
55	Phosphorylation	TDEQALLSSILAKTA CHHHHHHHHHHHHHH	19.04	28432305
56	Phosphorylation	DEQALLSSILAKTAS HHHHHHHHHHHHHHH	22.91	27097102
61	Phosphorylation	LSSILAKTASNIIDV HHHHHHHHHHCCCCH	29.70	23984901
63	Phosphorylation	SILAKTASNIIDVSA HHHHHHHHCCCCHHH	33.52	22108457
69	Phosphorylation	ASNIIDVSAADSQGM HHCCCCHHHHHHCCC	17.62	30181290
73	Phosphorylation	IDVSAADSQGMEQHE CCHHHHHHCCCHHHH	24.73	30181290
96	Phosphorylation	STRLAVLSSSLTHWK HHHHHHHHHCCCCHH	15.98	23984901
97	Phosphorylation	TRLAVLSSSLTHWKK HHHHHHHHCCCCHHH	25.80	23984901
98	Phosphorylation	RLAVLSSSLTHWKKL HHHHHHHCCCCHHHC	33.63	23984901
100	Phosphorylation	AVLSSSLTHWKKLPP HHHHHCCCCHHHCCC	27.86	23984901
140	Phosphorylation	SRIAAYAYSALSQIR HHHHHHHHHHHHCCC	5.04	-
141	Phosphorylation	RIAAYAYSALSQIRV HHHHHHHHHHHCCCC	17.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LTOR1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LTOR1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LTOR1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of LTOR1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.