LTBP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LTBP1_MOUSE
• UniProt AC: Q8CG19
• Protein Name: Latent-transforming growth factor beta-binding protein 1
• Gene Name: Ltbp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1712
• Subcellular Localization: Secreted .
• Protein Description: May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extracellular matrix (ECM)..
• Protein Sequence: MAGAWLRWGLLLWAGLLAWSAHGRVRRITYVVRPGPGLPAGALPLAGPPRTFNVALDARYSRSSTAASSRALAGPPAERTRRTSQPGGAALPGLRSPLPPEPARPGGPSRQLHSKAGAQTAVTRFAKHGRQVVRSQVQQDAQSAGGSRLQVQQKQQLQGINVCGGQCCHGWSKPPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGSKGKACEITAAQDTMPPAFGGQNPGSSWAPLEQAAKHTSTKKADTLPRVSPVAQMTLTLKPKPSMGLSQQIHPQVAPLSSQNVMIRHGQTQEYLLKPKYFPAPKVVSAEQSTEGSFSLRYGQEQGTAPFQVSNHTGRIKVVFTPSICKVTCTKGNCQNSCQKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVLGASMPKLYQHAQQQGKALGSHVIHSTHTLPLTMTSQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRIDSPGGQKVKEAQPGQSQVSYQGLPVQKTQTVHSTYSHQQLIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKQSYHGYTQMMECLQGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCSCKMGFGPDPTFSSCVPDPPVISEEKGPCYRLVSPGRHCMHPLSVHLTKQICCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRRRPIHQHIGKEAVYVKPKNTQPVAKSTHPPPLPAKEEPVEALTSSWEHGPRGAEPEVVTAPPEKEIPSLDQEKTRLEPGQPQLSPGVSTIHLHPQFPVVVEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYKFSEQLRKCVDIDECAQVRHLCSQGRCENTEGSFLCVCPAGFMASEEGTNCIDVDECLRPDMCRDGRCINTAGAFRCEYCDSGYRMSRRGYCEDIDECLKPSTCPEEQCVNTPGSYQCVPCTEGFRGWNGQCLDVDECLQPKVCTNGSCTNLEGSYMCSCHRGYSPTPDHRHCQDIDECQQGNLCMNGQCRNTDGSFRCTCGQGYQLSAAKDQCEDIDECEHHHLCSHGQCRNTEGSFQCVCNQGYRASVLGDHCEDINECLEDSSVCQGGDCINTAGSYDCTCPDGFQLNDNKGCQDINECAQPGLCGSHGECLNTQGSFHCVCEQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRVTEDSGVDRQPREEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVQGTAEFTEMCPRGKGLVPAGESSYDTGGENYKDADECLLFGEEICKNGYCLNTQPGYECYCKQGTYYDPVKLQCFDMDECQDPNSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCVQPTESNEQIEETDVYQDLCWEHLSEEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPMKDSDDYAQLCNIPVTGRRRPYGRDALVDFSEQYGPETDPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDMAKMTCVDVNECSELNNRMSLCKNAKCINTEGSYKCLCLPGYIPSDKPNYCTPLNSALNLDKESDLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
215	Phosphorylation	KGKACEITAAQDTMP CCCCCEEEECCCCCC	8.14	28059163
220	Phosphorylation	EITAAQDTMPPAFGG EEEECCCCCCCCCCC	21.35	28059163
313	Phosphorylation	FPAPKVVSAEQSTEG CCCCCEECCCCCCCC	29.13	26824392
317	Phosphorylation	KVVSAEQSTEGSFSL CEECCCCCCCCCEEE	21.67	28973931
321	Phosphorylation	AEQSTEGSFSLRYGQ CCCCCCCCEEEECCC	12.87	22942356
323	Phosphorylation	QSTEGSFSLRYGQEQ CCCCCCEEEECCCCC	17.40	22942356
339	N-linked_Glycosylation	TAPFQVSNHTGRIKV CCCEEEECCCCCEEE	37.57	-
370	N-linked_Glycosylation	QNSCQKGNTTTLISE CCCCCCCCCEEEECC	41.09	-
416	N-linked_Glycosylation	DKCQCPPNFTGKLCQ CCCCCCCCCCCCCCC	32.05	-
430	Phosphorylation	QIPVLGASMPKLYQH CCCCCCCCHHHHHHH	33.54	26643407
452	Phosphorylation	LGSHVIHSTHTLPLT HCCCEEEECCCCCCE	15.68	21183079
453	Phosphorylation	GSHVIHSTHTLPLTM CCCEEEECCCCCCEE	12.52	21183079
612	N-linked_Glycosylation	LQGYKRVNNTFCQDI HHHHHHHCCCCCCCH	45.95	-
665	Phosphorylation	VPDPPVISEEKGPCY CCCCCCCCCCCCCCE	39.68	22006019
818	Phosphorylation	EPGQPQLSPGVSTIH CCCCCCCCCCEEEEE	17.85	28418008
966	Hydroxylation	CRDGRCINTAGAFRC CCCCCEECCCCCEEC	27.74	-
1042	N-linked_Glycosylation	LQPKVCTNGSCTNLE CCCCCCCCCCCCCCC	34.94	-
1129	Hydroxylation	CSHGQCRNTEGSFQC CCCCCCCCCCCCEEE	50.54	-
1242	N-linked_Glycosylation	EDIDECVNNTVCDSH CCHHHHHHCCCCCCC	50.54	-
1357	N-linked_Glycosylation	CDNVLAPNVTKQECC CCCCCCCCCCCCCEE	48.78	-
1405	Phosphorylation	LVPAGESSYDTGGEN CCCCCCCCCCCCCCC	23.79	-
1588	Phosphorylation	RDALVDFSEQYGPET CCCCCCHHHHHCCCC	21.23	26824392
1591	Phosphorylation	LVDFSEQYGPETDPY CCCHHHHHCCCCCCH	30.51	26824392
1607	Phosphorylation	IQDRFLNSFEELQAE HHHHHHCCHHHHHHH	35.86	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LTBP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LTBP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LTBP1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LTBP1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.