LSG1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LSG1_MOUSE
• UniProt AC: Q3UM18
• Protein Name: Large subunit GTPase 1 homolog
• Gene Name: Lsg1
• Organism: Mus musculus (Mouse).
• Sequence Length: 644
• Subcellular Localization: Cytoplasm. Nucleus. Endoplasmic reticulum. Shuttles between the Cajal bodies in the nucleus and the endoplasmic reticulum..
• Protein Description: GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (By similarity)..
• Protein Sequence: MGRRRAPGGGSLGRVLIRQQTQRSRSHRHTDSWLHTSELNDGYDWGRLNLQSVTEQSSLEDFLATAELAGTEFVAEKLNIKFVPPEARTGLLSFEESQRIKKLHEENRQFLCIPRRPNWDRKTSPEELKQAEKDNFLKWRRQLVRLEEEQKLILTPFERNLDFWRQLWRVIERSDIVVQIVDARNPLLFRCEDLECYVKEIDAAKENVILINKADLLTAEQRFAWAVHFEKEGVKVIFWSALAETDHLNGDLKEEVDSVAGDTNKTESESSSLDANEIPHRDLISLSEESASDSGDSKYEDCQEDEEEDWQTCSEEDSVPEEEEGCNADSETQNRKNAENQQVNNDSYLVSKQELLELFKKLHTGKKVKDGQLTVGLVGYPNVGKSSTINTIMGNKKVSVSATPGHTKHFQTLYVEPGLCLCDCPGLVMPSFVSTKAEMICNGILPIDQMRDHVPPVSLVCQNIPRRVLEVTYGINIIKPREDEDPYRPPTSEELLTAYGCMRGFMTAHGQPDQPRSARYILKDYVGGKLLYCHPPPGKDPVAFQHQHQQLLESKVKGGELRLQPGKGRKAKQIENVVDKTFFHQENVRALTKGVQAVMGYKPGHGLVTAAAASAENVPGKPWKKHGNRNKKEKSRRLYKHLDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Methylation	PGGGSLGRVLIRQQT CCCCHHHHHHHHHCC	25.92	25058859
14	Dimethylation	PGGGSLGRVLIRQQT CCCCHHHHHHHHHCC	25.92	-
21	Phosphorylation	RVLIRQQTQRSRSHR HHHHHHCCHHCCCCC	20.01	29514104
93	Phosphorylation	EARTGLLSFEESQRI HHHCCCCCHHHHHHH	35.34	-
97	Phosphorylation	GLLSFEESQRIKKLH CCCCHHHHHHHHHHH	19.98	-
155	Phosphorylation	EEQKLILTPFERNLD HHHHEEECCHHHCHH	20.95	22871156
258	Phosphorylation	DLKEEVDSVAGDTNK CCHHHHHHHCCCCCC	21.02	25521595
263	Phosphorylation	VDSVAGDTNKTESES HHHHCCCCCCCCCCC	37.38	17242355
266	Phosphorylation	VAGDTNKTESESSSL HCCCCCCCCCCCCCC	46.98	25338131
268	Phosphorylation	GDTNKTESESSSLDA CCCCCCCCCCCCCCC	48.27	17242355
270	Phosphorylation	TNKTESESSSLDANE CCCCCCCCCCCCCCC	34.21	17242355
271	Phosphorylation	NKTESESSSLDANEI CCCCCCCCCCCCCCC	30.76	28973931
272	Phosphorylation	KTESESSSLDANEIP CCCCCCCCCCCCCCC	39.28	25195567
292	Phosphorylation	SLSEESASDSGDSKY ECCCCCCCCCCCCCC	41.40	25293948
294	Phosphorylation	SEESASDSGDSKYED CCCCCCCCCCCCCCC	41.84	25293948
297	Phosphorylation	SASDSGDSKYEDCQE CCCCCCCCCCCCCCC	40.43	25293948
399	Phosphorylation	IMGNKKVSVSATPGH HCCCCEEEEECCCCC	21.16	25338131
472	Phosphorylation	PRRVLEVTYGINIIK CHHHEEEEEEEEEEC	13.47	24719451
473	Phosphorylation	RRVLEVTYGINIIKP HHHEEEEEEEEEECC	22.60	24719451
517	Phosphorylation	GQPDQPRSARYILKD CCCCCCCCHHHHHHH	24.63	23737553
520	Phosphorylation	DQPRSARYILKDYVG CCCCCHHHHHHHCCC	15.43	23737553

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LSG1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LSG1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LSG1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LSG1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.