| UniProt ID | LRRT4_HUMAN | |
|---|---|---|
| UniProt AC | Q86VH4 | |
| Protein Name | Leucine-rich repeat transmembrane neuronal protein 4 | |
| Gene Name | LRRTM4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 590 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane Single-pass type I membrane protein. |
|
| Protein Description | May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity).. | |
| Protein Sequence | MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPGFQIPGAEQEYEHVSFHKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARESERQMNSPLQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECEMPHHMKPLPYYSYDQPVIGYCQAHQPLHVTKGYETVSPEQDESPGLELGRDHSFIATIARSAAPAIYLERIAN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 21 | Phosphorylation | VVLVLLPTLLLVMLT HHHHHHHHHHHHHHH | 29.97 | - | |
| 28 | Phosphorylation | TLLLVMLTGAQRACP HHHHHHHHCHHHHCC | 16.63 | - | |
| 58 | N-linked_Glycosylation | AFADIPENISGGSQG CEECCCCCCCCCCCC | 28.50 | UniProtKB CARBOHYD | |
| 117 | Phosphorylation | RLKELILSSNKITYL HHHHHHHCCCCEEEE | 25.52 | 25404012 | |
| 118 | Phosphorylation | LKELILSSNKITYLH HHHHHHCCCCEEEEC | 38.40 | 25404012 | |
| 126 | N-linked_Glycosylation | NKITYLHNKTFHPVP CCEEEECCCCCCCCC | 42.33 | UniProtKB CARBOHYD | |
| 195 | Phosphorylation | LGYNRLRSLSRNAFA CCHHHHHHHCHHHHH | 34.98 | 24702127 | |
| 197 | Phosphorylation | YNRLRSLSRNAFAGL HHHHHHHCHHHHHHH | 25.41 | 23927012 | |
| 235 | Phosphorylation | LFNLRSIYLQWNRIR HHCHHHHHHHHHHHH | 8.29 | 26699800 | |
| 291 | N-linked_Glycosylation | LDSNKLTNISQETVN CCCCCCCCCCHHHHH | 42.21 | UniProtKB CARBOHYD | |
| 429 | Phosphorylation | FHKIIAGSVALFLSV HHHHHHHHHHHHHHH | 8.66 | - | |
| 453 | Phosphorylation | SWKRYPASMKQLQQH HHHHCCHHHHHHHHH | 23.24 | 27135362 | |
| 461 | Phosphorylation | MKQLQQHSLMKRRRK HHHHHHHHHHHHHHH | 26.31 | 27422710 | |
| 495 (in isoform 2) | Phosphorylation | - | 21.69 | 22210691 | |
| 508 (in isoform 2) | Phosphorylation | - | 14.59 | 22210691 | |
| 560 | Phosphorylation | VSPEQDESPGLELGR CCCCCCCCCCCCCCC | 32.34 | 24076635 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LRRT4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LRRT4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LRRT4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of LRRT4_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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