| UniProt ID | LRRT3_HUMAN | |
|---|---|---|
| UniProt AC | Q86VH5 | |
| Protein Name | Leucine-rich repeat transmembrane neuronal protein 3 | |
| Gene Name | LRRTM3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 581 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane Single-pass type I membrane protein. |
|
| Protein Description | Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in the development and maintenance of the vertebrate nervous system.. | |
| Protein Sequence | MGFNVIRLLSGSAVALVIAPTVLLTMLSSAERGCPKGCRCEGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNYSICGKSTTERFDLARALPKPTFKPKLPRPKHESKPPLPPTVGATEPGPETDADAEHISFHKIIAGSVALFLSVLVILLVIYVSWKRYPASMKQLQQRSLMRRHRKKKRQSLKQMTPSTQEFYVDYKPTNTETSEMLLNGTGPCTYNKSGSRECEIPLSMNVSTFLAYDQPTISYCGVHHELLSHKSFETNAQEDTMETHLETELDLSTITTAGRISDHKQQLA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 21 | O-linked_Glycosylation | VALVIAPTVLLTMLS HHHHHHHHHHHHHHH | 18.11 | 29351928 | |
| 77 | Ubiquitination | YNSLQKLKYNQFKGL HHHHHHCCCCCCCCC | 49.55 | 30230243 | |
| 126 | N-linked_Glycosylation | NRISYFLNNTFRPVT CCHHHHHCCCCCCCC | 35.28 | UniProtKB CARBOHYD | |
| 168 | Phosphorylation | SLHLRSNSLRTIPVR HHHHHCCCCCCCCEE | 22.07 | - | |
| 329 | Phosphorylation | SLVNWLKSFKGLREN HHHHHHHHCCCCCCC | 29.98 | 24719451 | |
| 357 | N-linked_Glycosylation | NVIDAVKNYSICGKS CHHHHHCCCCCCCCC | 29.23 | UniProtKB CARBOHYD | |
| 358 | Phosphorylation | VIDAVKNYSICGKST HHHHHCCCCCCCCCH | 8.16 | 23403867 | |
| 359 | Phosphorylation | IDAVKNYSICGKSTT HHHHCCCCCCCCCHH | 22.31 | 23403867 | |
| 364 | Phosphorylation | NYSICGKSTTERFDL CCCCCCCCHHHHHHH | 26.33 | 23403867 | |
| 365 | Phosphorylation | YSICGKSTTERFDLA CCCCCCCHHHHHHHH | 35.84 | 23403867 | |
| 366 | Phosphorylation | SICGKSTTERFDLAR CCCCCCHHHHHHHHH | 32.05 | 23403867 | |
| 424 | Phosphorylation | FHKIIAGSVALFLSV HHHHHHHHHHHHHHH | 8.66 | - | |
| 450 | Acetylation | KRYPASMKQLQQRSL HHCCHHHHHHHHHHH | 45.41 | 20167786 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LRRT3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LRRT3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LRRT3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of LRRT3_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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