LRRT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRRT1_MOUSE
• UniProt AC: Q8K377
• Protein Name: Leucine-rich repeat transmembrane neuronal protein 1
• Gene Name: Lrrtm1
• Organism: Mus musculus (Mouse).
• Sequence Length: 522
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein. Accumulates extensively in the endoplasmic reticulum of transfected nonneuronal cells.
• Protein Description: Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level..
• Protein Sequence: MDFLLLGLCLHWLLRRPSGVVLCLLGACFQMLPAAPSGCPGQCRCEGRLLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITELANTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLIKVNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPYLQTLQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLSNFQGRYDANLQCASPEYAQGEDVLDAVYAFHLCEDGAEPTSGHLLSVAVTNRSDLTPPESSATTLVDGGEGHDGTFEPITVALPGGEHAENAVQIHKVVTGTMALIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQTMHQMAAMSAQEYYVDYKPNHIEGALVIINEYGSCTCHQQPARECEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	N-linked_Glycosylation	LLYCEALNLTEAPHN EEEEEECCCCCCCCC	52.55	-
63	N-linked_Glycosylation	NLTEAPHNLSGLLGL CCCCCCCCHHHHHHH	34.54	-
76	Phosphorylation	GLSLRYNSLSELRAG HHHHCCCCHHHHHCC	25.08	28066266
78	Phosphorylation	SLRYNSLSELRAGQF HHCCCCHHHHHCCCC	34.11	28066266
130	N-linked_Glycosylation	NQITELANTTFRPMP HHHHHHHCCCCCCCC	52.88	-
381	N-linked_Glycosylation	LLSVAVTNRSDLTPP EEEEEEECHHHCCCC	34.56	-
463	S-palmitoylation	SLRQLRQCFVTQRRK HHHHHHHHHHHHHHH	2.09	28680068

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRRT1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRRT1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRRT1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LRRT1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.