LRRK1_MOUSE - dbPTM
LRRK1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LRRK1_MOUSE
UniProt AC Q3UHC2
Protein Name Leucine-rich repeat serine/threonine-protein kinase 1
Gene Name Lrrk1 {ECO:0000312|MGI:MGI:2142227}
Organism Mus musculus (Mouse).
Sequence Length 2014
Subcellular Localization Cytoplasm .
Protein Description
Protein Sequence MAGTSQRPPSMYWCVGTEGLAVCPGPAMETHNGAEDMGSKLSLPGGSSTVQCPSMEEIHTAYKQRNLSRARDLLRGVCEESESSQEKGQLLSIAAAHGDLETVQFLLTEKRVELPTEPTDDNPAVVAAHFGHAEVVRELLESLPGPCTPQRLLNWMLALACQRGHLEVVKLLVLTHGADPENYAVRKNEFPVIVRLPLYAAIKAGNEDIAIFLLRHGAYFCSYILLDSPEPSKHLLRKYFIEASALPSSYPGKIALRVKWSHLKLPWVDLDWLLDISCQITELDLSANCLPSLPSIIPWGLINLKKLNLSNNQLGELPCVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTASKNYLERLFEEENATNWIGLRKLQELDLADNRLTELPVQFMHSFKSLTSLNVSRNNLKSFPDPWSCPLKCCKASKNALESLPDKMAVFWKSHLRDADFSENSLKEVPLGLFQLDALMFLRLQGNQLLSLPPQEKWTCTQLKTLDLSRNQLGKNEDGLKTKRISLFTTRGRQRSGTETASMLEFPAFLSESLEVLCLNDNHLDAVPPSVCLLKNLSELYLGNNPGLRELPPELGQLGNLWQLDIEDLNISNVPAEVRKEGPKATLSFLRAQLRKAEKCKLMKMILVGPPRQGKSTLLEILQTGKAPQLAHSEATIRTTKWELQRPAGSKAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPDITFKHLHEISCKNLEGQEGLRQLIFHVTCNMKDVGSTIGCQKLAGRLIPRSYISLQEAVLAEQQRRSLGDQVQYLTDRQLDQLVEQTPGNDIKDYEDLQSAISFLIETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIQAEDLRMLLVGTGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHSMRHPMANTIQRVFKMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGSQRNRCSTFRVRRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGIKIICQSEMRDFSAMAFITDHVNSLIDQWFPALTATESDGTPLMEQYVPCPVCEASWAQHADPNERSESVQYFDMEDCVLTAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHTEGENSILGQGGSGTVIYQARYQGQPVAVKRFHIKKFKNSANAPADTMLRHLRAMDAMKNFSDFRQEASMLHALQHPCIVSLIGISIHPLCFALELAPLGSLNTVLSENAKDSSFMPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLSAKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIVKKLSKGIRPVLGQPEEVQFHRLQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYMLPCGKQSAFFSSQSQEYTVVFWDGKEESRNYTVVNTEKGLLEVQRMTCPGMKLSCQLKVQSSVWIATEDQKIYIYSLKGMCPLSVPQQALDTPAVVTCFLAVPVIKKNSFLVLAGLADGLVAVFPVARGTPKESCSYLCSHTANRSKFCIPDEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCTILDISRRLEPYAAPSMVTSLVCSSDCRGEEMVWCLDDKANCLVMYHSATYQLCARYFCGDPNPLRDTFSVQPSVLETPGSHKTTSKGPVEECIADVSIMYSEELGTQILTHQDSLTDYCSMSSYSSSPPHQDPRSPSSLPSSLTSYSSVPFSANYEDSDRLQEPSVTSDRTEHDLSPMDGETFSQHLQAVKVLAVKDLIWVPRHGGDIIVIGLEKDSGAQRGRVIAVLKARELNRHGVLVDAAVVAKDTVVCSFANENTEWCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
342PhosphorylationDISSNKLSHLPPGFL
ECCCCCHHCCCCCCH		25.2921454597
352PhosphorylationPPGFLHLSKLQKLTA
CCCCHHHHHHHHHHC		22.1421454597
360PhosphorylationKLQKLTASKNYLERL
HHHHHHCCHHHHHHH		19.0521454597
669PhosphorylationKAPQLAHSEATIRTT
CCCCHHCCCCCCCCC		24.2625338131
672PhosphorylationQLAHSEATIRTTKWE
CHHCCCCCCCCCCEE		13.6226824392
675PhosphorylationHSEATIRTTKWELQR
CCCCCCCCCCEEEEC		28.9529895711
676PhosphorylationSEATIRTTKWELQRP
CCCCCCCCCEEEECC		25.0629895711
823PhosphorylationRQLIFHVTCNMKDVG
HHHHEEEEECCCCCC		6.92-
1038PhosphorylationFIARMLISLAEMDLQ
HHHHHHHHHHHHHHH		19.98-
1054MethylationFENKKNTKSRNRKVT
HHCCCCCCCCCCEEE		57.73-
1063PhosphorylationRNRKVTIYSFTGSQR
CCCEEEEEEECCCCC		6.5922817900
1066PhosphorylationKVTIYSFTGSQRNRC
EEEEEEECCCCCCCE		29.9525338131
1068PhosphorylationTIYSFTGSQRNRCST
EEEEECCCCCCCEEE		23.9429176673
1074PhosphorylationGSQRNRCSTFRVRRN
CCCCCCEEEEEEECC		27.6129514104
1075PhosphorylationSQRNRCSTFRVRRNQ
CCCCCEEEEEEECCC		21.0629514104
1258PhosphorylationGGSGTVIYQARYQGQ
CCCEEEEEEEEECCC		7.5622817900
1287PhosphorylationSANAPADTMLRHLRA
CCCCCHHHHHHHHHH		21.8829176673
1368PhosphorylationMLTQKIAYQIASGLA
HHHHHHHHHHHHHHH		12.1521454597
1376PhosphorylationQIASGLAYLHKKNII
HHHHHHHHHHHCCEE		17.8721454597
1430PhosphorylationGVEGTPGYQAPEIRP
CCCCCCCCCCCCCCC		11.6022817900
1846PhosphorylationSMSSYSSSPPHQDPR
CCCCCCCCCCCCCCC		36.1923384938
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LRRK1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LRRK1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LRRK1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LRRK1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LRRK1_MOUSE

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Related Literatures of Post-Translational Modification

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