LRRF2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRRF2_RAT
• UniProt AC: Q4V7E8
• Protein Name: Leucine-rich repeat flightless-interacting protein 2
• Gene Name: Lrrfip2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 437
• Protein Description: May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity)..
• Protein Sequence: MGTPGSGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQRESSSKDITGTHWSRASTPKRRDMMYDSIKDRSSRVSSLLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEKHGLVIIPESTPNGDVNHEPVVGAITAVSQEAAQVLESAGEGPLDVRLRKLAEEKDELLSQIRKLKLQLEEERQKCSRNDGMSGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAAENAEKIEDELKAEKRKLQRELRTAQDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	TPVKDRFSAEDEALS CCCCCCCCHHHHHHH	31.48	29779826
60	Phosphorylation	LERQQRESSSKDITG HHHHHHHHCCCCCCC	41.94	16641100
68	Phosphorylation	SSKDITGTHWSRAST CCCCCCCCCCCCCCC	16.12	16641100
105	Phosphorylation	DEKSDKQYAENYTRP CHHCHHHHHHHCCCC	22.94	23984901
109	Phosphorylation	DKQYAENYTRPSSRN HHHHHHHCCCCCCCC	8.81	23984901
110	Phosphorylation	KQYAENYTRPSSRNS HHHHHHCCCCCCCCC	47.92	23984901
113	Phosphorylation	AENYTRPSSRNSASA HHHCCCCCCCCCCCC	38.34	22673903
114	Phosphorylation	ENYTRPSSRNSASAT HHCCCCCCCCCCCCC	37.86	22108457
117	Phosphorylation	TRPSSRNSASATTPL CCCCCCCCCCCCCCC	23.61	27097102
119	Phosphorylation	PSSRNSASATTPLSG CCCCCCCCCCCCCCC	26.43	27097102
121	Phosphorylation	SRNSASATTPLSGNS CCCCCCCCCCCCCCC	26.84	27097102
122	Phosphorylation	RNSASATTPLSGNSS CCCCCCCCCCCCCCC	23.19	27097102
125	Phosphorylation	ASATTPLSGNSSRRG CCCCCCCCCCCCCCC	36.81	23712012
128	Phosphorylation	TTPLSGNSSRRGSGD CCCCCCCCCCCCCCC	28.84	27097102
129	Phosphorylation	TPLSGNSSRRGSGDT CCCCCCCCCCCCCCH	29.96	23712012
133	Phosphorylation	GNSSRRGSGDTSSLI CCCCCCCCCCHHHCC	31.51	23712012
136	Phosphorylation	SRRGSGDTSSLIDPD CCCCCCCHHHCCCCC	24.60	23712012
137	Phosphorylation	RRGSGDTSSLIDPDT CCCCCCHHHCCCCCC	28.08	27097102
138	Phosphorylation	RGSGDTSSLIDPDTS CCCCCHHHCCCCCCC	31.28	27097102
144	Phosphorylation	SSLIDPDTSLSELRE HHCCCCCCCHHHHHH	36.63	27097102
145	Phosphorylation	SLIDPDTSLSELRES HCCCCCCCHHHHHHH	36.96	27097102
147	Phosphorylation	IDPDTSLSELRESLS CCCCCCHHHHHHHHH	34.06	27097102
152	Phosphorylation	SLSELRESLSEVEEK CHHHHHHHHHHHHHH	30.66	25575281
154	Phosphorylation	SELRESLSEVEEKYK HHHHHHHHHHHHHHH	49.20	25575281
159	Acetylation	SLSEVEEKYKKAMVS HHHHHHHHHHHHHHC	49.19	22902405
227	Acetylation	QHKMDELKEGLRQRD HHHHHHHHHHHHHHH	47.92	22902405
293	Acetylation	LRKLAEEKDELLSQI HHHHHHHHHHHHHHH	48.27	22902405
298	Phosphorylation	EEKDELLSQIRKLKL HHHHHHHHHHHHHHH	35.86	25575281
392	Acetylation	EKIEDELKAEKRKLQ HHHHHHHHHHHHHHH	53.07	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRRF2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRRF2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRRF2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of LRRF2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.