LRIG2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRIG2_MOUSE
• UniProt AC: Q52KR2
• Protein Name: Leucine-rich repeats and immunoglobulin-like domains protein 2
• Gene Name: Lrig2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1054
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Cytoplasm.
• Protein Sequence: MAAAPRGIWEQRRLGCGLGPLARLLILAQALRLLPAARAGLCPAPCACRLPLLDCSRRKLPAPSWRALSGPLPSDISSLDLSHNRLSNWNNTLESQTLQEVKMNYNELTEIPYFGEPTPNITLLSLVHNLIPEINAEAFELYSALESLDLSSNIISEIKTSSFPRMSLKYLNLSNNRISTLEAGCFDNLSDSLLVVKLNRNRISMIPPKVFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTGVNKGWLYGLRMLQQLYMSQNAIEKISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNDISWAIEDASEAFSGLKSLTKLILQGNRIKSVTQKAFIGLESLEYLDLNNNAIMSIQENAFSQTHLKGLVLNTSSLLCDCHLKWLLQWLVDNNFHHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPESTIALRGVNVTLTCTAVSSSDSPMSTIWRKDSEILYDVDIENFVRYRQQDGEALEYTSVLRLFSVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPTPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNIAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCLMSNTLGTERGHIYLNVISSPNCDSSQSSIGHEDDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKNEDYSITNTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSHQQLMPPANGYTHRGTDGGAGTRVICSDCYDNANIYSRTREYCPYTYIAEEDVLDQALSSLMVQMPKETFLSHPPQDAANLESLIPSAEREPAAFPTNHERMTENLPFSQRSSEIFQRPLWNMNRELGLLPFSQQPVLESPELTERDPNCSSPVTCRRLHDHAFDFSRTRIIQDGTEGT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	N-linked_Glycosylation	HNRLSNWNNTLESQT CCCCCCCCHHHCHHH	35.54	-
120	N-linked_Glycosylation	YFGEPTPNITLLSLV CCCCCCCCEEHHHHH	42.21	-
162	Phosphorylation	ISEIKTSSFPRMSLK HHHHHHCCCCCCCEE	44.49	-
172	N-linked_Glycosylation	RMSLKYLNLSNNRIS CCCEEEEECCCCCEE	38.03	-
188	N-linked_Glycosylation	LEAGCFDNLSDSLLV EHHCCCCCCCCCEEE	22.61	-
273	N-linked_Glycosylation	ELELEHNNLTGVNKG HHCCHHCCCCCCCHH	40.67	-
440	N-linked_Glycosylation	HLKGLVLNTSSLLCD HHHHHEECHHHHHHH	30.36	-
467	N-linked_Glycosylation	NNFHHSVNVSCAHPE CCCCCCCEEEECCHH	24.01	-
513	N-linked_Glycosylation	TIALRGVNVTLTCTA CEEECCEEEEEEEEE	24.71	-
570	N-linked_Glycosylation	VLRLFSVNFTDEGKY EEEEEEEECCCCCEE	32.66	-
588	N-linked_Glycosylation	VTNHFGSNYSQKAKL EECCCCCCCCHHEEE	40.63	-
596	Phosphorylation	YSQKAKLTVNEMPSF CCHHEEEEHHHCCHH	22.15	-
611	Phosphorylation	LKTPMDLTIRTGAMA HCCCCCEEECCCCCC	12.26	-
686	N-linked_Glycosylation	IAGGLSANASLTVLE CCCCCCCCCEEEEEE	27.04	-
727	N-linked_Glycosylation	GSPAPRLNWTKDDGP CCCCCCCCCCCCCCC	45.72	-
768	Phosphorylation	GKYTCLMSNTLGTER HHHEEEEECCCCCCC	17.45	-
905	Phosphorylation	RVICSDCYDNANIYS EEEECCCCCCCCCHH	19.75	26032504
911	Phosphorylation	CYDNANIYSRTREYC CCCCCCCHHHCCHHC	7.60	26032504
1019	Phosphorylation	VLESPELTERDPNCS CCCCCCCCCCCCCCC	27.58	30482847
1024	N-linked_Glycosylation	ELTERDPNCSSPVTC CCCCCCCCCCCCCCH	42.46	-
1026	Phosphorylation	TERDPNCSSPVTCRR CCCCCCCCCCCCHHH	44.30	25293948
1027	Phosphorylation	ERDPNCSSPVTCRRL CCCCCCCCCCCHHHC	26.11	25293948
1030	Phosphorylation	PNCSSPVTCRRLHDH CCCCCCCCHHHCHHC	12.04	25293948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRIG2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRIG2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRIG2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LRIG2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.