LRFN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRFN2_HUMAN
• UniProt AC: Q9ULH4
• Protein Name: Leucine-rich repeat and fibronectin type-III domain-containing protein 2
• Gene Name: LRFN2
• Organism: Homo sapiens (Human).
• Sequence Length: 789
• Subcellular Localization: Membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane.
• Protein Description: Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery (By similarity)..
• Protein Sequence: METLLGGLLAFGMAFAVVDACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPLSFSFGGNPLHCNCELLWLRRLERDDDLETCGSPGGLKGRYFWHVREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEVSIVQLPHLSNSTSRTAPPKSRLSDITGSSKTSRGGGGSGGGEPPKSPPERAVLVSEVTTTSALVKWSVSKSAPRVKMYQLQYNCSDDEVLIYRMIPASNKAFVVNNLVSGTGYDLCVLAMWDDTATTLTATNIVGCAQFFTKADYPQCQSMHSQILGGTMILVIGGIIVATLLVFIVILMVRYKVCNHEAPSKMAAAVSNVYSQTNGAQPPPPSSAPAGAPPQGPPKVVVRNELLDFTASLARASDSSSSSSLGSGEAAGLGRAPWRIPPSAPRPKPSLDRLMGAFASLDLKSQRKEELLDSRTPAGRGAGTSARGHHSDREPLLGPPAARARSLLPLPLEGKAKRSHSFDMGDFAAAAAGGVVPGGYSPPRKVSNIWTKRSLSVNGMLLPFEESDLVGARGTFGSSEWVMESTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	N-linked_Glycosylation	PKYCVCQNLSESLGT CCCCCCCCHHHHHCC	40.17	UniProtKB CARBOHYD
54	Phosphorylation	PPDIDRRTVELRLGG CCCCCCCEEEEEECC	21.16	22210691
82	Phosphorylation	MTGLVDLTLSRNTIS CCCCEEEEECCCCCC	20.44	24719451
87	Phosphorylation	DLTLSRNTISHIQPF EEEECCCCCCCCCCC	23.81	-
89	Phosphorylation	TLSRNTISHIQPFSF EECCCCCCCCCCCCC	16.70	-
179	Phosphorylation	MVNLHQLSLDHNLLD HHHHHHHCCCCCHHH	25.77	-
332	N-linked_Glycosylation	PDDRLVGNSSRTAVY CCCCCCCCCCCEEEE	29.36	UniProtKB CARBOHYD
341	N-linked_Glycosylation	SRTAVYDNGTLDIFI CCEEEEECCEEEEEE	27.88	UniProtKB CARBOHYD
384	N-linked_Glycosylation	VQLPHLSNSTSRTAP EECCCCCCCCCCCCC	56.52	UniProtKB CARBOHYD
397	Phosphorylation	APPKSRLSDITGSSK CCCCCHHHHCCCCCC	26.34	25278378
400	Phosphorylation	KSRLSDITGSSKTSR CCHHHHCCCCCCCCC	35.68	24670416
402	Phosphorylation	RLSDITGSSKTSRGG HHHHCCCCCCCCCCC	21.73	24670416
403	Phosphorylation	LSDITGSSKTSRGGG HHHCCCCCCCCCCCC	41.10	25278378
405	Phosphorylation	DITGSSKTSRGGGGS HCCCCCCCCCCCCCC	26.13	25278378
406	Phosphorylation	ITGSSKTSRGGGGSG CCCCCCCCCCCCCCC	32.44	25278378
420	Phosphorylation	GGGEPPKSPPERAVL CCCCCCCCCCHHEEE	52.00	22210691
435	Phosphorylation	VSEVTTTSALVKWSV EEEEEEHHHHHHEEC	19.95	22210691
472	Phosphorylation	IYRMIPASNKAFVVN EEEEEECCCCEEEEE	33.24	-
629	Phosphorylation	SSSSSLGSGEAAGLG CCCCCCCCCCCCCCC	38.46	22210691
676	Phosphorylation	RKEELLDSRTPAGRG HHHHHHHCCCCCCCC	37.71	20393185
686	Phosphorylation	PAGRGAGTSARGHHS CCCCCCCCCCCCCCC	20.76	-
708	Phosphorylation	PPAARARSLLPLPLE CCCHHHHHCCCCCCC	33.02	32142685
719	Acetylation	LPLEGKAKRSHSFDM CCCCCCCCCCCCCCH	58.90	19413330
721	Phosphorylation	LEGKAKRSHSFDMGD CCCCCCCCCCCCHHH	23.83	22210691
723	Phosphorylation	GKAKRSHSFDMGDFA CCCCCCCCCCHHHHH	24.96	22210691
742	Phosphorylation	GGVVPGGYSPPRKVS CCCCCCCCCCCCCCC	24.74	27732954
743	Phosphorylation	GVVPGGYSPPRKVSN CCCCCCCCCCCCCCC	31.53	27732954
749	Phosphorylation	YSPPRKVSNIWTKRS CCCCCCCCCCCCCCE	26.15	19413330
753	Phosphorylation	RKVSNIWTKRSLSVN CCCCCCCCCCEEEEC	16.87	19413330
756	Phosphorylation	SNIWTKRSLSVNGML CCCCCCCEEEECCEE	26.93	28348404
758	Phosphorylation	IWTKRSLSVNGMLLP CCCCCEEEECCEEEC	18.12	28348404
769	Phosphorylation	MLLPFEESDLVGARG EEECCCHHHCCCCCC	29.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRFN2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRFN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRFN2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of LRFN2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.