LRCH4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRCH4_MOUSE
• UniProt AC: Q921G6
• Protein Name: Leucine-rich repeat and calponin homology domain-containing protein 4
• Gene Name: Lrch4
• Organism: Mus musculus (Mouse).
• Sequence Length: 680
• Protein Sequence: MAAAVAGPLAAGGEEAAASVSLPGSPGLPGSRSAERALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLKCLNPALGNLTALTYLNLSRNQLSSLPPYICQLPLRVLIISNNKLGALPPDISTLGSLRQLDVSSNELQSLPVELCSLRSLRDLNVRRNQLSTLPDELGDLPLVRLDFSCNRISRIPVSFCRLRHLQVVLLDSNPLQSPPAQICLKGKLHIFKYLTMEAGRRGAALGDLVPSRPPSFSPCPAEDLFPGRRYDGGLDSGFHSVDSGSKRWSGNESTDDFSELSFRISELARDPRGPRQPREDGAGDGDLEQIDFIDSHVPGEDEDRSAAEEQLPSELSLVAGDVEKPSSSRREEPAGEERRRPDTLQLWQERERKQQQQSGGWGSPRKDSVLKRGIRAAGAGASAPSTQATCNGPPKSSTTQLGVSGGQGAPTPPPTSQDPLPVSGPVTAPVPRPLGSIQRPNSFLFRSSSQSGSSPSSPESVLRPRPFPQEKELISQLRQVLESRLQQPLPEDLAEALANGVLLCQLANQLRPRSVPFIHVPSPAVPKLSALKSRKNVESFLEACRKMGVPEADLCSPSDLLRGTAQGLQTVLEAVILVGGKAPLPVQPSSGLGGFLLFYVVFMLLLYVVYTRLLGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	GGEEAAASVSLPGSP CCCHHCCEECCCCCC	13.91	25619855
21	Phosphorylation	EEAAASVSLPGSPGL CHHCCEECCCCCCCC	26.76	23984901
25	Phosphorylation	ASVSLPGSPGLPGSR CEECCCCCCCCCCCH	17.54	26824392
31	Phosphorylation	GSPGLPGSRSAERAL CCCCCCCCHHHHHHH	22.56	25619855
64	Phosphorylation	FPRGAARSYDLSDIT CCCCCCCCCCHHHCC	20.48	30635358
68	Phosphorylation	AARSYDLSDITQADL CCCCCCHHHCCHHHH	24.86	30635358
183	Phosphorylation	VELCSLRSLRDLNVR HHHHHHHHHHHHCCC	32.80	24759943
275	Phosphorylation	ALGDLVPSRPPSFSP CCCCCCCCCCCCCCC	50.36	26239621
279	Phosphorylation	LVPSRPPSFSPCPAE CCCCCCCCCCCCCHH	40.83	21082442
281	Phosphorylation	PSRPPSFSPCPAEDL CCCCCCCCCCCHHHC	29.90	26824392
304	Phosphorylation	GLDSGFHSVDSGSKR CCCCCCEECCCCCCC	25.92	25338131
307	Phosphorylation	SGFHSVDSGSKRWSG CCCEECCCCCCCCCC	42.69	25338131
309	Phosphorylation	FHSVDSGSKRWSGNE CEECCCCCCCCCCCC	24.01	25266776
313	Phosphorylation	DSGSKRWSGNESTDD CCCCCCCCCCCCCCC	35.46	21082442
317	Phosphorylation	KRWSGNESTDDFSEL CCCCCCCCCCCHHHH	40.93	25266776
318	Phosphorylation	RWSGNESTDDFSELS CCCCCCCCCCHHHHH	33.15	22817900
322	Phosphorylation	NESTDDFSELSFRIS CCCCCCHHHHHHHHH	44.62	28066266
422	Phosphorylation	ERKQQQQSGGWGSPR HHHHHHHHCCCCCCC	34.63	28066266
427	Phosphorylation	QQSGGWGSPRKDSVL HHHCCCCCCCHHHHH	18.28	28066266
432	Phosphorylation	WGSPRKDSVLKRGIR CCCCCHHHHHHHHHH	32.17	19367708
454	Glutathionylation	APSTQATCNGPPKSS CCCCCCCCCCCCCCC	6.59	24333276
506	Phosphorylation	GSIQRPNSFLFRSSS CCCCCCCCEEEECCC	26.47	26824392
511	Phosphorylation	PNSFLFRSSSQSGSS CCCEEEECCCCCCCC	27.32	26745281
512	Phosphorylation	NSFLFRSSSQSGSSP CCEEEECCCCCCCCC	28.30	26745281
513	Phosphorylation	SFLFRSSSQSGSSPS CEEEECCCCCCCCCC	29.61	27600695
515	Phosphorylation	LFRSSSQSGSSPSSP EEECCCCCCCCCCCC	42.46	26745281
517	Phosphorylation	RSSSQSGSSPSSPES ECCCCCCCCCCCCHH	44.30	26745281
518	Phosphorylation	SSSQSGSSPSSPESV CCCCCCCCCCCCHHH	32.12	26745281
520	Phosphorylation	SQSGSSPSSPESVLR CCCCCCCCCCHHHCC	61.55	25266776
521	Phosphorylation	QSGSSPSSPESVLRP CCCCCCCCCHHHCCC	35.75	25266776
524	Phosphorylation	SSPSSPESVLRPRPF CCCCCCHHHCCCCCC	29.81	25266776
578	Phosphorylation	ANQLRPRSVPFIHVP HHHHCCCCCCEEECC	36.50	21183079
586	Phosphorylation	VPFIHVPSPAVPKLS CCEEECCCCCCCCHH	25.13	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRCH4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRCH4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRCH4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LRCH4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.