LRC59_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRC59_RAT
• UniProt AC: Q5RJR8
• Protein Name: Leucine-rich repeat-containing protein 59
• Gene Name: Lrrc59
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 307
• Subcellular Localization: Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1..
• Protein Description: Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity)..
• Protein Sequence: MTKTGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATVLDLSCNKLSTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNRLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQQAKEAKERELRKREKAEEKERRRKEYDAQKASKREQEKKPKKETNQAPKSKSGSRPRKPPPRKHNRSWAVLKGLLLLLLLCVAGGLVVCRVTGLQQQPLCTSVNAIYDNAVQGLRHHEILQWVLQTDSQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTKTGSKG -------CCCCCCCC	8.60	-
2	Acetylation	------MTKTGSKGG ------CCCCCCCCC	37.00	-
23	Phosphorylation	DGNELDLSLSDLNEV CCCEECCCHHHHCCC	26.03	27097102
25	Phosphorylation	NELDLSLSDLNEVPV CEECCCHHHHCCCCH	36.35	27097102
71	Acetylation	LVKLDLSKNKLQQLP HHHHCCCCCHHHCCC	66.45	72589785
73	Acetylation	KLDLSKNKLQQLPAD HHCCCCCHHHCCCCC	51.95	22902405
73	Succinylation	KLDLSKNKLQQLPAD HHCCCCCHHHCCCCC	51.95	-
73	Succinylation	KLDLSKNKLQQLPAD HHCCCCCHHHCCCCC	51.95	-
108	Acetylation	PVSFAQLKNLKWLDL CCCHHHHCCCCCCCC	48.42	22902405
111	Acetylation	FAQLKNLKWLDLKDN HHHHCCCCCCCCCCC	55.92	22902405
116	Acetylation	NLKWLDLKDNPLDPV CCCCCCCCCCCCCHH	55.94	22902405
135	Acetylation	AGDCLDEKQCKQCAN HHHCCCHHHHHHHHH	61.74	25786129
149	Acetylation	NKVLQHMKAVQADQE HHHHHHHHHHHHHHH	43.19	22902405
305	Phosphorylation	QWVLQTDSQQ----- HHHHHHCCCC-----	33.59	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRC59_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRC59_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRC59_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of LRC59_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.