LRC25_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRC25_HUMAN
• UniProt AC: Q8N386
• Protein Name: Leucine-rich repeat-containing protein 25
• Gene Name: LRRC25
• Organism: Homo sapiens (Human).
• Sequence Length: 305
• Subcellular Localization: Membrane ; Single-pass type I membrane protein . Cytoplasm .
• Protein Description: Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy. [PubMed: 29288164 Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.]
• Protein Sequence: MGGTLAWTLLLPLLLRESDSLEPSCTVSSADVDWNAEFSATCLNFSGLSLSLPHNQSLRASNVILLDLSGNGLRELPVTFFAHLQKLEVLNVLRNPLSRVDGALAARCDLDLQADCNCALESWHDIRRDNCSGQKPLLCWDTTSSQHNLSAFLEVSCAPGLASATIGAVVVSGCLLLGLAIAGPVLAWRLWRCRVARSRELNKPWAAQDGPKPGLGLQPRYGSRSAPKPQVAVPSCPSTPDYENMFVGQPAAEHQWDEQGAHPSEDNDFYINYKDIDLASQPVYCNLQSLGQAPMDEEEYVIPGH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	N-linked_Glycosylation	EFSATCLNFSGLSLS EEEEEEEECCCCEEE	31.05	UniProtKB CARBOHYD
55	N-linked_Glycosylation	LSLSLPHNQSLRASN CEEECCCCHHHCCCC	31.06	UniProtKB CARBOHYD
130	N-linked_Glycosylation	WHDIRRDNCSGQKPL HHHHHCCCCCCCCCE	21.75	UniProtKB CARBOHYD
148	N-linked_Glycosylation	DTTSSQHNLSAFLEV ECCCCCCCHHHHEEE	28.23	UniProtKB CARBOHYD
284	Phosphorylation	DLASQPVYCNLQSLG CCCCCCEEECHHHHC	5.15	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRC25_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRC25_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRC25_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of LRC25_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.