dbPTM

LRC18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LRC18_HUMAN
UniProt AC	Q8N456
Protein Name	Leucine-rich repeat-containing protein 18
Gene Name	LRRC18
Organism	Homo sapiens (Human).
Sequence Length	261
Subcellular Localization	Cytoplasm.
Protein Description	May be involved in the regulation of spermatogenesis and sperm maturation..
Protein Sequence	MVKGEKGPKGKKITLKVARNCIKITFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENLYVVEEKDLCAACLRKCQNARDNLNRIKNMATTTPRKTIFPNLISPNSMAKDSWEDWRIRLTSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	GPKGKKITLKVARNC CCCCCCEEEEEECCE	29.43	24719451
82	Phosphorylation	LRWLDLHSNYIDKLP CCCHHCCCHHHHHCC	38.33	25159151
84	Phosphorylation	WLDLHSNYIDKLPES CHHCCCHHHHHCCHH	17.32	27762562
96	Phosphorylation	PESIGQMTSLLYLNV CHHHHHCCEEEEEEC	14.34	-
162	Phosphorylation	LLNNIPVSISKLPKL HHHCCCCCHHHCCCC	18.78	25693802
164	Phosphorylation	NNIPVSISKLPKLKK HCCCCCHHHCCCCCC	22.19	25693802
170	Ubiquitination	ISKLPKLKKLNIKRN HHHCCCCCCCCCCCC	62.43	-
185	Phosphorylation	PFPKPGESEIFIDSI CCCCCCCCCEEHHHH	41.74	30622161
191	Phosphorylation	ESEIFIDSIRRLENL CCCEEHHHHHHHCCE	17.12	30622161
245	Phosphorylation	PNLISPNSMAKDSWE CCCCCCCCCCCCCHH	24.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LRC18_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LRC18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LRC18_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of LRC18_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LRC18_HUMAN

Related Literatures of Post-Translational Modification