dbPTM

LRC14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LRC14_HUMAN
UniProt AC	Q15048
Protein Name	Leucine-rich repeat-containing protein 14 {ECO:0000305}
Gene Name	LRRC14 {ECO:0000312\|HGNC:HGNC:20419}
Organism	Homo sapiens (Human).
Sequence Length	493
Subcellular Localization	Cytoplasm .
Protein Description	Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB..
Protein Sequence	MHTLVFLSTRQVLQCQPAACQALPLLPRELFPLLFKVAFMDKKTVVLRELVHTWPFPLLSFQQLLQECAHCSRALLQERPSTESMQAVILGLTARLHTSEPGASTQPLCRKHALRVLDMTGLLDDGVEQDPGTMSMWDCTAAVARTCIAQQQGGAAEPGPAPIPVEVRVDLRVNRASYAFLREALRSSVGSPLRLCCRDLRAEDLPMRNTVALLQLLDAGCLRRVDLRFNNLGLRGLSVIIPHVARFQHLASLRLHYVHGDSRQPSVDGEDNFRYFLAQMGRFTCLRELSMGSSLLSGRLDQLLSTLQSPLESLELAFCALLPEDLRFLARSPHAAHLKKLDLSGNDLSGSQLAPFQGLLQASAATLLHLELTECQLADTQLLATLPILTQCASLRYLGLYGNPLSMAGLKELLRDSVAQAELRTVVHPFPVDCYEGLPWPPPASVLLEASINEEKFARVEAELHQLLLASGRAHVLWTTDIYGRLAADYFSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
252	Phosphorylation	ARFQHLASLRLHYVH HHHHHHHHCEEEECC	22.00	24719451
266	Phosphorylation	HGDSRQPSVDGEDNF CCCCCCCCCCCHHHH	25.22	28555341
293	Phosphorylation	LRELSMGSSLLSGRL HHHHHHCCHHHHHHH	14.79	22468782
294	Phosphorylation	RELSMGSSLLSGRLD HHHHHCCHHHHHHHH	27.83	28355574
297	Phosphorylation	SMGSSLLSGRLDQLL HHCCHHHHHHHHHHH	27.45	22468782
411	Ubiquitination	PLSMAGLKELLRDSV CCHHHHHHHHHHHHH	45.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LRC14_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LRC14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LRC14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSN3_HUMAN	COPS3	physical	19295130
RBX1_HUMAN	RBX1	physical	19295130
CUL2_HUMAN	CUL2	physical	19295130
ELOB_HUMAN	TCEB2	physical	19295130
ELOC_HUMAN	TCEB1	physical	19295130

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LRC14_HUMAN

Related Literatures of Post-Translational Modification