| UniProt ID | LPP60_MOUSE | |
|---|---|---|
| UniProt AC | A0JNU3 | |
| Protein Name | 60 kDa lysophospholipase | |
| Gene Name | Aspg | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 564 | |
| Subcellular Localization | ||
| Protein Description | Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities.. | |
| Protein Sequence | MARAMGPERRLLAIYTGGTIGMRSEGGVLVPGRGLAAVLKTLHMFHDEEYAQAHSLPEDTLVLPPASPDQRIIYTVLECQPLFDSSDMTITEWVQIAQTIERHYAQYQGFVVIHGTDTMAFAASVLSFMLENLQKPVVLTGAQVPIHALWSDGRENLLGALLMAGQYVIPEVCLFFQNQLFRGNRTTKVDARRFAAFCSPNLPPLATVGADVTINRELVRKACGKSHLVVHSSMEPDVGLLRLYPGIPASLVRTFLQPPLKGVVMETFGSGNGPTKPDLLQELRVAAEQGLIIVNCTHCLQGAVTSDYASGMAMAGAGIVSGFDMTSEAALAKLSYVLGQPGLSLNDRKKLLAKDLRGEMTLPATDVLLQDGMLGCRVAWLLSMNGSQEADTMKDVLLPGLALAAAHAGDLDTLQAFVELDRDLNLKDYSGQTPLHVAARRGHAAVVTMLLQRGADVDARNEDGQSPLLLAVRGRHQSVIGLLRAAGARLSPQELEDVGTELCRLASRGDSEGLRAWWQAGADLGQPDYDGHCALQVAEAAGNADVVALLQSFKDSVCAQPQPH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 15 | Phosphorylation | ERRLLAIYTGGTIGM CCEEEEEECCCCCCC | 8.17 | 24719451 | |
| 19 | Phosphorylation | LAIYTGGTIGMRSEG EEEECCCCCCCCCCC | 18.72 | 24719451 | |
| 24 | Phosphorylation | GGTIGMRSEGGVLVP CCCCCCCCCCCEEEC | 31.53 | 29899451 | |
| 225 | Ubiquitination | LVRKACGKSHLVVHS HHHHHHCCCCEEEEC | 34.29 | 22790023 | |
| 261 | Ubiquitination | TFLQPPLKGVVMETF HHCCCCCCEEEEECC | 56.27 | 22790023 | |
| 276 | Ubiquitination | GSGNGPTKPDLLQEL CCCCCCCCHHHHHHH | 39.40 | 22790023 | |
| 354 | Ubiquitination | DRKKLLAKDLRGEMT HHHHHHHHHHCCCCC | 58.21 | - | |
| 354 | Malonylation | DRKKLLAKDLRGEMT HHHHHHHHHHCCCCC | 58.21 | 26320211 | |
| 387 | Phosphorylation | WLLSMNGSQEADTMK HHHHCCCCCCCCCHH | 21.61 | 17203969 | |
| 393 | Oxidation | GSQEADTMKDVLLPG CCCCCCCHHHHHHHH | 3.43 | 17203969 | |
| 427 | Ubiquitination | LDRDLNLKDYSGQTP HCCCCCCCCCCCCCC | 54.25 | 22790023 | |
| 448 | Phosphorylation | RGHAAVVTMLLQRGA CCCHHHHHHHHHCCC | 8.76 | 20469934 | |
| 478 | Phosphorylation | AVRGRHQSVIGLLRA EECCCCHHHHHHHHH | 15.02 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LPP60_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LPP60_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LPP60_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of LPP60_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-387, AND MASSSPECTROMETRY. | |
