LOXL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LOXL1_HUMAN
• UniProt AC: Q08397
• Protein Name: Lysyl oxidase homolog 1
• Gene Name: LOXL1
• Organism: Homo sapiens (Human).
• Sequence Length: 574
• Subcellular Localization: Secreted, extracellular space .
• Protein Description: Active on elastin and collagen substrates..
• Protein Sequence: MALARGSRQLGALVWGACLCVLVHGQQAQPGQGSDPARWRQLIQWENNGQVYSLLNSGSEYVPAGPQRSESSSRVLLAGAPQAQQRRSHGSPRRRQAPSLPLPGRVGSDTVRGQARHPFGFGQVPDNWREVAVGDSTGMARARTSVSQQRHGGSASSVSASAFASTYRQQPSYPQQFPYPQAPFVSQYENYDPASRTYDQGFVYYRPAGGGVGAGAAAVASAGVIYPYQPRARYEEYGGGEELPEYPPQGFYPAPERPYVPPPPPPPDGLDRRYSHSLYSEGTPGFEQAYPDPGPEAAQAHGGDPRLGWYPPYANPPPEAYGPPRALEPPYLPVRSSDTPPPGGERNGAQQGRLSVGSVYRPNQNGRGLPDLVPDPNYVQASTYVQRAHLYSLRCAAEEKCLASTAYAPEATDYDVRVLLRFPQRVKNQGTADFLPNRPRHTWEWHSCHQHYHSMDEFSHYDLLDAATGKKVAEGHKASFCLEDSTCDFGNLKRYACTSHTQGLSPGCYDTYNADIDCQWIDITDVQPGNYILKVHVNPKYIVLESDFTNNVVRCNIHYTGRYVSATNCKIVQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Phosphorylation	GPQRSESSSRVLLAG CCCCCCCCCCEEECC	20.36	30576142
73	Phosphorylation	PQRSESSSRVLLAGA CCCCCCCCCEEECCC	35.37	30576142
91	Phosphorylation	QQRRSHGSPRRRQAP HHHHHCCCCCCCCCC	15.15	30576142
99	Phosphorylation	PRRRQAPSLPLPGRV CCCCCCCCCCCCCCC	45.71	-
141	Methylation	GDSTGMARARTSVSQ CCCCCCCCCCCCCCC	18.73	24387897
154	Phosphorylation	SQQRHGGSASSVSAS CCCCCCCCCHHHHHH	29.57	22210691
161	Phosphorylation	SASSVSASAFASTYR CCHHHHHHHHHHHCC	19.20	22210691
165	Phosphorylation	VSASAFASTYRQQPS HHHHHHHHHCCCCCC	21.37	22210691
197	Phosphorylation	NYDPASRTYDQGFVY CCCCCCCCCCCCEEE	29.02	21214269
226	Phosphorylation	VASAGVIYPYQPRAR HHCCCCEECCCCCCC	8.09	21214269
283	O-linked_Glycosylation	HSLYSEGTPGFEQAY CCCCCCCCCCCHHHC	19.04	OGP
392	Phosphorylation	VQRAHLYSLRCAAEE HHHHHHHHHHHHHHH	18.72	24719451
512	"2',4',5'-topaquinone"	SPGCYDTYNADIDCQ CCCCHHHCCCCCCCE	12.88	-
512	Other	SPGCYDTYNADIDCQ CCCCHHHCCCCCCCE	12.88	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LOXL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LOXL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LOXL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FBLN5_HUMAN	FBLN5	physical	14745449

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.