LONP2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LONP2_ARATH
• UniProt AC: O64948
• Protein Name: Lon protease homolog 2, peroxisomal {ECO:0000255|HAMAP-Rule:MF_03121}
• Gene Name: LON2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 888
• Subcellular Localization: Peroxisome matrix .
• Protein Description: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix (By similarity). Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import..
• Protein Sequence: MAETVELPSRLAILPFRNKVLLPGAIIRIRCTSHSSVTLVEQELWQKEEKGLIGILPVRDDAEGSSIGTMINPGAGSDSGERSLKFLVGTTDAQKSDAKDQQDLQWHTRGVAARALHLSRGVEKPSGRVTYVVVLEGLSRFNVQELGKRGPYSVARITSLEMTKAELEQVKQDPDFVALSRQFKTTAMELVSVLEQKQKTGGRTKVLLETVPIHKLADIFVASFEMSFEEQLSMLDSVDLKVRLSKATELVDRHLQSIRVAEKITQKVEGQLSKSQKEYLLRQQMRAIKEELGDNDDDEDDVAALERKMQAAGMPSNIWKHAQRELRRLKKMQPQQPGYNSSRVYLELLADLPWDKASEEHELDLKAAKERLDSDHYGLAKVKQRIIEYLAVRKLKPDARGPVLCFVGPPGVGKTSLASSIAAALGRKFVRLSLGGVKDEADIRGHRRTYIGSMPGRLIDGLKRVGVCNPVMLLDEIDKTGSDVRGDPASALLEVLDPEQNKSFNDHYLNVPYDLSKVVFVATANRVQPIPPPLLDRMELIELPGYTQEEKLKIAMRHLIPRVLDQHGLSSEFLKIPEAMVKNIIQRYTREAGVRSLERNLAALARAAAVMVAEHEQSLPLSKDVQKLTSPLLNGRMAEGGEVEMEVIPMGVNDHEIGGTFQSPSALVVDETMLEKILGPPRFDDSEAADRVASAGVSVGLVWTTFGGEVQFVEATSMVGKGEMHLTGQLGDVIKESAQLALTWVRARASDFKLALAGDMNVLDGRDIHIHFPAGAVPKDGPSAGVTLVTALVSLFSQKRVRADTAMTGEMTLRGLVLPVGGIKDKILAAHRYGIKRVILPQRNSKDLVEVPAAVLSSLEVILAKRMEDVLENAFEGGCPWRNNYSKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
130	Phosphorylation	EKPSGRVTYVVVLEG CCCCCCEEEEEEEEC	14.83	19880383
131	Phosphorylation	KPSGRVTYVVVLEGL CCCCCEEEEEEEECH	6.59	19880383
139	Phosphorylation	VVVLEGLSRFNVQEL EEEEECHHHCCHHHH	45.76	19880383
152	Phosphorylation	ELGKRGPYSVARITS HHHHCCCCCHHHEEE	20.71	23111157
158	Phosphorylation	PYSVARITSLEMTKA CCCHHHEEEEECCHH	23.00	23111157
159	Phosphorylation	YSVARITSLEMTKAE CCHHHEEEEECCHHH	21.69	23111157
783	Phosphorylation	AVPKDGPSAGVTLVT CCCCCCCCHHHHHHH	43.09	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LONP2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LONP2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LONP2_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of LONP2_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.