LMTK2_MOUSE - dbPTM
LMTK2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LMTK2_MOUSE
UniProt AC Q3TYD6
Protein Name Serine/threonine-protein kinase LMTK2
Gene Name Lmtk2
Organism Mus musculus (Mouse).
Sequence Length 1471
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Phosphorylates PPP1C, phosphorylase b and CFTR..
Protein Sequence MPGPPASPPPPMLLLLLLLTVGCARAAPLPQTGAGEVPVVEVPSLFVILSVCSLLILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSIQSPAEVFTLSVPNISLPAPSQFQASVEGLKSQVARHSLNYIQEIGSGWFGKVLLGETYTGTSVARVIVKELKVSASPKEQDTFLKSGEPYYILQHPNVLQCVGQCVEAIPYLLVFEFCDLGDLKAYLHNEQEHVRGDSQTMLLQRMACEIAAGLAAMHKLHFLHSDLALRNCYLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFNNAAQPYANLSDLDVLNQVIRERDMKLPKPQLEQPYSDRWYEVLQFCWLPPDKRPAAEDVHRLLTYLRMQSQRDSEVDFEQQWTALKPDTNSRDASSSAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEAAKHDHFDEQGRGHPDEALSYSSMFFPVEVFENSLSDPGPGKQDDSGQEVPVRAPGVVPVFDAHNLSVGSDYYIQLEEKSSSNLGLDPPALLTTEVDKLERAGAEEPRTEEDFFQSSAHPKEASSTEDSRATSIPGSPFNLFSDLDKADDLPSHQKIFDLMELNGVQADFKPAILSSSLDDPKDTCQSDKEKPHKLLDQGPLCLSESLLHQDHFDPLSVQELSENFLFLQEKNLLKGSLTTKEQVSDLQTELKNAGFTSALLESPQRGSESSELEFLENTLDFPLSQGDTRGQNEGAGVRRHSGTSPQASPALLTEEGSPTAPTDPILKPEETKSFRDVRVPEDSICLELGPDPVTVGVEIPATDAKTLDGGNRPPDVTCQSKEALSLTNRHPILVNDITAQGSVESCLPESRQDLQNEPFSEDPLSVSSLEKHSEAAETLNQLNSKAAPEDAALASALSSDSTSQDSLLEDSLSTPIPTSEQSVETPDSLDSVDVREALLESLGSHTPRKLLPPDKPADSGYETENLESPEWTLHPAPEGTADSDAAAAGDSGHSSLPPNPVIVISDAGDGHRGAEGPPQSFTLGPQSSYRDSAYFSDNDSEPDKKPEEVPGTSANALVLVKGQSPPESVVPEESSDVREGCLEAPQDKPDQSRVSTLQNSCHSELQETLQPTPADASRESCPVNDEASSPLSLLNSEPSSCDDLDTQEDRPCTLASTGTNTNELLAYMSSTLDKSLPSHLESSKLKEPDIEGKYLGKLCVSGMLDLSEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDDTEHPVPIIVSNDDGRHLRSLLKPSAAEAIEQLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGHCGGEAHGPGPSSPAASSSSPYLGRCMNSESSTDEEGGGFEWDDDFSPDPFMSKTTSLLGSKPSLQTSKYFSPPPPARSAEQSWPHVSPCSRFSISPANIASFSLTHLTDSDIEQGGSSEDGDKD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
176UbiquitinationLKVSASPKEQDTFLK
CCCCCCHHHHCCCCC		66.5622790023
407PhosphorylationEDVHRLLTYLRMQSQ
HHHHHHHHHHHHHHH		25.7124719451
413PhosphorylationLTYLRMQSQRDSEVD
HHHHHHHHHCCCCCC		20.1724719451
438PhosphorylationDTNSRDASSSAAFPI
CCCCCCCCHHCHHHH		29.1628066266
439PhosphorylationTNSRDASSSAAFPIL
CCCCCCCHHCHHHHH		26.2222817900
440PhosphorylationNSRDASSSAAFPILD
CCCCCCHHCHHHHHH		22.5628066266
524PhosphorylationGPGKQDDSGQEVPVR
CCCCCCCCCCCCCCC		51.1428066266
602PhosphorylationSAHPKEASSTEDSRA
CCCCCCCCCCCCHHC		38.5929899451
603PhosphorylationAHPKEASSTEDSRAT
CCCCCCCCCCCHHCC		42.7529899451
604PhosphorylationHPKEASSTEDSRATS
CCCCCCCCCCHHCCC		41.1229899451
607PhosphorylationEASSTEDSRATSIPG
CCCCCCCHHCCCCCC		19.9929899451
610PhosphorylationSTEDSRATSIPGSPF
CCCCHHCCCCCCCCC		26.5327180971
611PhosphorylationTEDSRATSIPGSPFN
CCCHHCCCCCCCCCC		26.2921743459
615PhosphorylationRATSIPGSPFNLFSD
HCCCCCCCCCCCCCC		22.4426824392
621PhosphorylationGSPFNLFSDLDKADD
CCCCCCCCCCCCCCC		40.1921183079
656PhosphorylationKPAILSSSLDDPKDT
CHHHHHCCCCCCCCC		32.2327841257
736PhosphorylationELKNAGFTSALLESP
HHHHCCCHHHHHHCC		16.5126239621
737PhosphorylationLKNAGFTSALLESPQ
HHHCCCHHHHHHCCC		18.0425619855
742PhosphorylationFTSALLESPQRGSES
CHHHHHHCCCCCCCC		26.7125521595
747PhosphorylationLESPQRGSESSELEF
HHCCCCCCCCHHHHH		36.1729899451
781PhosphorylationGAGVRRHSGTSPQAS
CCCCCCCCCCCCCCC		41.7927742792
783PhosphorylationGVRRHSGTSPQASPA
CCCCCCCCCCCCCCC		40.0027742792
784PhosphorylationVRRHSGTSPQASPAL
CCCCCCCCCCCCCCE		20.6627742792
788PhosphorylationSGTSPQASPALLTEE
CCCCCCCCCCEECCC		12.8827742792
793PhosphorylationQASPALLTEEGSPTA
CCCCCEECCCCCCCC		32.6121183079
797PhosphorylationALLTEEGSPTAPTDP
CEECCCCCCCCCCCC		23.5121082442
799PhosphorylationLTEEGSPTAPTDPIL
ECCCCCCCCCCCCCC		47.1422817900
802PhosphorylationEGSPTAPTDPILKPE
CCCCCCCCCCCCCHH		52.5225293948
811PhosphorylationPILKPEETKSFRDVR
CCCCHHHCCCCCCCC		30.2625293948
882PhosphorylationNDITAQGSVESCLPE
CEEECCCCHHHHCCH		15.6128973931
905PhosphorylationPFSEDPLSVSSLEKH
CCCCCCCCHHHHHHH		25.9128066266
907PhosphorylationSEDPLSVSSLEKHSE
CCCCCCHHHHHHHHH		26.3228066266
908PhosphorylationEDPLSVSSLEKHSEA
CCCCCHHHHHHHHHH		38.0928066266
984PhosphorylationALLESLGSHTPRKLL
HHHHHCCCCCCHHCC		29.4928066266
986PhosphorylationLESLGSHTPRKLLPP
HHHCCCCCCHHCCCC		26.8728066266
1072PhosphorylationPQSSYRDSAYFSDND
CCCCCCCCCCCCCCC		18.8325293948
1074PhosphorylationSSYRDSAYFSDNDSE
CCCCCCCCCCCCCCC		13.9425293948
1076PhosphorylationYRDSAYFSDNDSEPD
CCCCCCCCCCCCCCC		23.8727087446
1080PhosphorylationAYFSDNDSEPDKKPE
CCCCCCCCCCCCCCC		58.2325521595
1092PhosphorylationKPEEVPGTSANALVL
CCCCCCCCCCCEEEE		20.7025293948
1093PhosphorylationPEEVPGTSANALVLV
CCCCCCCCCCEEEEE		25.9926643407
1104PhosphorylationLVLVKGQSPPESVVP
EEEECCCCCCHHCCC		51.6025521595
1108PhosphorylationKGQSPPESVVPEESS
CCCCCCHHCCCCCCC		33.9023984901
1274PhosphorylationLRAFNLHSLSSESED
HHHHCHHHCCCCCCC		32.8723737553
1276PhosphorylationAFNLHSLSSESEDDT
HHCHHHCCCCCCCCC		34.7721082442
1277PhosphorylationFNLHSLSSESEDDTE
HCHHHCCCCCCCCCC		50.8921082442
1279PhosphorylationLHSLSSESEDDTEHP
HHHCCCCCCCCCCCC		48.5521082442
1283PhosphorylationSSESEDDTEHPVPII
CCCCCCCCCCCCCEE		48.8123737553
1334PhosphorylationFFDDVTVYLFDQETP
EECCEEEEEECCCCC		7.7122807455
1358PhosphorylationEAHGPGPSSPAASSS
CCCCCCCCCCCCCCC		55.6726643407
1359PhosphorylationAHGPGPSSPAASSSS
CCCCCCCCCCCCCCC		22.9925266776
1363PhosphorylationGPSSPAASSSSPYLG
CCCCCCCCCCCCCCC		32.6228066266
1364PhosphorylationPSSPAASSSSPYLGR
CCCCCCCCCCCCCCC		30.0626643407
1365PhosphorylationSSPAASSSSPYLGRC
CCCCCCCCCCCCCCC		32.6026643407
1366PhosphorylationSPAASSSSPYLGRCM
CCCCCCCCCCCCCCC		21.3626643407
1368PhosphorylationAASSSSPYLGRCMNS
CCCCCCCCCCCCCCC		24.6026643407
1413PhosphorylationGSKPSLQTSKYFSPP
CCCCCCCCCCCCCCC		32.26-
1414PhosphorylationSKPSLQTSKYFSPPP
CCCCCCCCCCCCCCC		16.64-
1416PhosphorylationPSLQTSKYFSPPPPA
CCCCCCCCCCCCCCC		14.7323527152
1418PhosphorylationLQTSKYFSPPPPARS
CCCCCCCCCCCCCCC		33.1523527152
1429PhosphorylationPARSAEQSWPHVSPC
CCCCHHHCCCCCCCC		33.80-
1437PhosphorylationWPHVSPCSRFSISPA
CCCCCCCCCCCCCHH		39.48-
1452PhosphorylationNIASFSLTHLTDSDI
HHHEEEEEECCHHHH		17.4021183079
1464PhosphorylationSDIEQGGSSEDGDKD
HHHHCCCCCCCCCCC		37.0622817900
1465PhosphorylationDIEQGGSSEDGDKD-
HHHCCCCCCCCCCC-		42.8722817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LMTK2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LMTK2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LMTK2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LMTK2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LMTK2_MOUSE

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Related Literatures of Post-Translational Modification

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