LMNB2_CHICK - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LMNB2_CHICK
• UniProt AC: P14732
• Protein Name: Lamin-B2
• Gene Name: LMNB2
• Organism: Gallus gallus (Chicken).
• Sequence Length: 600
• Subcellular Localization: Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side.
• Protein Description: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin..
• Protein Sequence: MSGTPIRGTPGGTPLSPTRISRLQEKEELRQLNDRLAVYIDRVRALELENDRLLVKISEKEEVTTREVSGIKNLYESELADARRVLDETAKERARLQIEIGKLRAELEEFNKSYKKKDADLSVAQGRIKDLEVLFHRSEAELNTVLNEKRSLEAEVADLRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEDLDFRKNVFEEEIRETRKRHEHRLVEVDTSRQQEYENKMAQALEDLRNQHDEQVKLYKMELEQTYQAKLENAILASDQNDKAAGAAREELKEARMRIESLSHQLSGLQKQASATEDRIRELKETMAGERDKFRKMLDAKEREMTEMRDQMQLQLTEYQELLDVKLALDMEISAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSSSSTSLVRSSRGKRRRIEAEELSGSGTSGIGTGSISGSSSSSSFQMSQQASATGSISIEEIDLEGKYVQLKNNSEKDQSLGNWRLKRQIGDGEEIAYKFTPKYVLRAGQTVTIWGADAGVSHSPPSVLVWKNQGSWGTGGNIRTYLVNSDGEEVAVRTVTKSVVVRENEEEEDEADFGEEDLFNQQGDPRTTSRGCLVM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGTPIRGT ------CCCCCCCCC	51.91	-
2	Phosphorylation	------MSGTPIRGT ------CCCCCCCCC	51.91	23106611
9	Phosphorylation	SGTPIRGTPGGTPLS CCCCCCCCCCCCCCC	14.65	23106611
18	Phosphorylation	GGTPLSPTRISRLQE CCCCCCHHHHHHHHH	36.94	21736374
400	Phosphorylation	VSRATSSSSSSSTSL EEEEECCCCCCCHHH	33.72	-
404	Phosphorylation	TSSSSSSSTSLVRSS ECCCCCCCHHHHHCC	24.78	-
410	Phosphorylation	SSTSLVRSSRGKRRR CCHHHHHCCCCCCCE	19.53	-
411	Phosphorylation	STSLVRSSRGKRRRI CHHHHHCCCCCCCEE	34.19	-
597	Farnesylation	PRTTSRGCLVM---- CCCCCCCEECC----	2.22	-
597	Methylation	PRTTSRGCLVM---- CCCCCCCEECC----	2.22	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
410	S	Phosphorylation	Kinase	PRKCA	P04409	GPS
411	S	Phosphorylation	Kinase	PRKCA	P04409	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LMNB2_CHICK !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LMNB2_CHICK !!

Protein-Protein Interaction

Oops, there are no PPI records of LMNB2_CHICK !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.