dbPTM

LMNB1_CHICK - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LMNB1_CHICK
UniProt AC	P14731
Protein Name	Lamin-B1
Gene Name	LMNB1
Organism	Gallus gallus (Chicken).
Sequence Length	584
Subcellular Localization	Nucleus inner membrane Lipid-anchor Nucleoplasmic side.
Protein Description	Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin..
Protein Sequence	MAAAVAPLSPQPRGAAASAALSPTRISRLQEKEELRQLNDRLAVYIDKVRSLETENSALQRRVSEREQVCGREISGLKELFETELADARKTLDDTARERAKLQIELGKLRAEHEQVLSSYAKKDSDLNAAQVKLREFEAALNAKEAALATALGDKRSQEEELEDLRDQIAQLEVSLAAAKKELADETLQKVDLENRCQSLIEDLEFRKNVYEEEIKETRRKHETRLVEVDSGRQIEYEYKLAQALKEIREQHDAQVKLYKEELEQTYSSKLENIRQSSEMHSCTANTVREELHESRMRIETLSSHIADIQKESRAWQDRVHELEDTLSKERENYRKILAENEREVAEMRNQMQQQFSDYEQLLDVKLALDMEISAYRKLLESEEERLRLSPGPSSRVTVSRASSSRSVRTTRGKRKRIDVEESEASSSVSISHSASATGNISIEEIDVDGKFIRLKNTSEQDQPMGGWEMIRKIGDTSASYRYTSRYVLKAGQTVTIWAANAGVTASPPTDLIWKNQNSWGTGEDVKVVLKNSQGEEVAQRSTVFKTTVNEGEEEEEEGEEEILEDVIHQQGSPRKPERSCVVM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAVAPLS ------CCCCCCCCC	12.25	-
9	Phosphorylation	AAAVAPLSPQPRGAA CCCCCCCCCCCCCHH	22.04	23106611
581	Farnesylation	PRKPERSCVVM---- CCCCCCCCCCC----	3.15	-
581	Methylation	PRKPERSCVVM---- CCCCCCCCCCC----	3.15	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LMNB1_CHICK !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LMNB1_CHICK !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LMNB1_CHICK !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
KCMA1_CHICK	KCNMA1	physical	22174833

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LMNB1_CHICK

Related Literatures of Post-Translational Modification