LMNA_CHICK - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LMNA_CHICK
• UniProt AC: P13648
• Protein Name: Lamin-A
• Gene Name: LMNA
• Organism: Gallus gallus (Chicken).
• Sequence Length: 657
• Subcellular Localization: Nucleus.
• Protein Description: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin..
• Protein Sequence: MSTPSQRRSGRGGGPSGTPLSPTRITRLQEKEDLQELNDRLAVYIDKVRSLELENAGLRLRITESEEVVSREVSGIKAAYEAELADARKTLDSVAKERARLQLELSKVREEHKELKARNAKKEADLLAAQARLKDLEALLNSKEAALSTALGEKRNLENEVRDLRAQVAKLEGALSEAKKQLQDEMLRRVDAENRLQTLKEELEFQKNIYSEELRETKRRHETRLVEIDNGRQQEFESKLAEALQDLRRQHEDQIRHYRDELEKTYGAKLENAKQSAERNSSMAGAAHEELQQTHIRIDSLSAELSQLQKQLAAKEAKLREVEEALSREREGGRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEINAYRKLLEGEEERLRLSPSPSSQRGARSSGLQHSGAGSAKKRRLEDGEGREGREGRTSFSHHARTSGRVGVEEVDLEGRFVRLRNKSNEDQALGNWQVKRQNGDDPPLTYRFPPKFTLKAGQAVTIWASGAGATHSPPSDVVWKAQSSWGSGDSLRTALINSNGEEVAMRKLVRTVIINDDDEDEEDDEVSIHHRHHHSGCSGSADPAEYNLRSRTVLCGTCGQPADKGSAAAASSASSASTVTVSRGYRSSGGGIGEGLLGRSYVLGGAGPRRQAPAPQGCSIM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSTPSQRRS ------CCCHHHCCC	49.37	-
389	Phosphorylation	EEERLRLSPSPSSQR HHHHHHCCCCCCCCC	19.52	23106611
459	Phosphorylation	FVRLRNKSNEDQALG EEEEECCCCCCHHHC	49.34	23106611
571	Phosphorylation	IHHRHHHSGCSGSAD EECCCCCCCCCCCCC	36.82	23106611
574	Phosphorylation	RHHHSGCSGSADPAE CCCCCCCCCCCCHHH	39.03	23106611
624	Phosphorylation	VSRGYRSSGGGIGEG EECCCCCCCCCCCCC	32.24	23106611
654	Methylation	QAPAPQGCSIM---- CCCCCCCCCCC----	1.78	-
654	Farnesylation	QAPAPQGCSIM---- CCCCCCCCCCC----	1.78	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LMNA_CHICK !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LMNA_CHICK !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LMNA_CHICK !!

Protein-Protein Interaction

Oops, there are no PPI records of LMNA_CHICK !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.