LIRB5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LIRB5_HUMAN
• UniProt AC: O75023
• Protein Name: Leukocyte immunoglobulin-like receptor subfamily B member 5
• Gene Name: LILRB5
• Organism: Homo sapiens (Human).
• Sequence Length: 590
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: May act as receptor for class I MHC antigens..
• Protein Sequence: MTLTLSVLICLGLSVGPRTCVQAGTLPKPTLWAEPASVIARGKPVTLWCQGPLETEEYRLDKEGLPWARKRQNPLEPGAKAKFHIPSTVYDSAGRYRCYYETPAGWSEPSDPLELVATGFYAEPTLLALPSPVVASGGNVTLQCDTLDGLLTFVLVEEEQKLPRTLYSQKLPKGPSQALFPVGPVTPSCRWRFRCYYYYRKNPQVWSNPSDLLEILVPGVSRKPSLLIPQGSVVARGGSLTLQCRSDVGYDIFVLYKEGEHDLVQGSGQQPQAGLSQANFTLGPVSRSHGGQYRCYGAHNLSPRWSAPSDPLDILIAGLIPDIPALSVQPGPKVASGENVTLLCQSWHQIDTFFLTKEGAAHPPLCLKSKYQSYRHQAEFSMSPVTSAQGGTYRCYSAIRSYPYLLSSPSYPQELVVSGPSGDPSLSPTGSTPTPGPEDQPLTPTGLDPQSGLGRHLGVVTGVSVAFVLLLFLLLFLLLRHRHQSKHRTSAHFYRPAGAAGPEPKDQGLQKRASPVADIQEEILNAAVKDTQPKDGVEMDARAAASEAPQDVTYAQLHSLTLRREATEPPPSQEREPPAEPSIYAPLAIH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTLTLSVLI ------CCEEEEHHH	28.57	24043423
4	Phosphorylation	----MTLTLSVLICL ----CCEEEEHHHHH	14.07	24043423
6	Phosphorylation	--MTLTLSVLICLGL --CCEEEEHHHHHCC	15.05	24043423
14	Phosphorylation	VLICLGLSVGPRTCV HHHHHCCCCCCCHHH	24.19	24043423
88	Phosphorylation	AKFHIPSTVYDSAGR CEEECCCEEECCCCC	20.10	24719451
90	Phosphorylation	FHIPSTVYDSAGRYR EECCCEEECCCCCEE	12.31	24719451
139	N-linked_Glycosylation	PVVASGGNVTLQCDT CEEECCCCEEEEECC	27.42	UniProtKB CARBOHYD
225	Phosphorylation	PGVSRKPSLLIPQGS CCCCCCCCEEECCCC	38.55	23312004
279	N-linked_Glycosylation	QAGLSQANFTLGPVS CCCCCCCCEEECCCC	23.85	16335952
339	N-linked_Glycosylation	PKVASGENVTLLCQS CCCCCCCCCEEEEEC	35.28	UniProtKB CARBOHYD
434	O-linked_Glycosylation	SPTGSTPTPGPEDQP CCCCCCCCCCCCCCC	40.75	OGP
443	O-linked_Glycosylation	GPEDQPLTPTGLDPQ CCCCCCCCCCCCCCC	26.03	OGP
445	O-linked_Glycosylation	EDQPLTPTGLDPQSG CCCCCCCCCCCCCCC	45.18	OGP
489	Phosphorylation	RHQSKHRTSAHFYRP HHHHCCCCCCCEECC	29.95	23312004
490	Phosphorylation	HQSKHRTSAHFYRPA HHHCCCCCCCEECCC	21.50	26657352
491	Phosphorylation	QSKHRTSAHFYRPAG HHCCCCCCCEECCCC	9.01	24719451
494	Phosphorylation	HRTSAHFYRPAGAAG CCCCCCEECCCCCCC	13.06	23312004
514	Phosphorylation	QGLQKRASPVADIQE CCCHHCCCCCHHHHH	24.76	24972180
515	Phosphorylation	GLQKRASPVADIQEE CCHHCCCCCHHHHHH	25.08	24719451
546	Phosphorylation	MDARAAASEAPQDVT CCHHHHHHCCCCCCC	29.57	27486199
553	Phosphorylation	SEAPQDVTYAQLHSL HCCCCCCCHHHHHHH	22.79	28857561
554	Phosphorylation	EAPQDVTYAQLHSLT CCCCCCCHHHHHHHE	7.69	15474475
559	Phosphorylation	VTYAQLHSLTLRREA CCHHHHHHHEEECCC	31.48	28857561
560	Phosphorylation	TYAQLHSLTLRREAT CHHHHHHHEEECCCC	3.49	-
561	Phosphorylation	YAQLHSLTLRREATE HHHHHHHEEECCCCC	22.64	28857561
562	Phosphorylation	AQLHSLTLRREATEP HHHHHHEEECCCCCC	6.19	24719451
584	Phosphorylation	PPAEPSIYAPLAIH- CCCCCCCCCCCCCC-	13.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LIRB5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LIRB5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LIRB5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of LIRB5_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-279, AND MASSSPECTROMETRY.
PubMed: 16335952