LIPE_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LIPE_MOUSE
• UniProt AC: Q9WVG5
• Protein Name: Endothelial lipase
• Gene Name: Lipg
• Organism: Mus musculus (Mouse).
• Sequence Length: 500
• Subcellular Localization: Secreted.
• Protein Description: Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin (By similarity)..
• Protein Sequence: MRNTVFLLGFWSVYCYFPAGSITTLRPQGSLRDEHHKPTGVPATARPSVAFNIRTSKDPEQEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFESWLHKLVSALQMREKDANVVVVDWLPLAHQLYTDAVNNTRVVGQRVAGMLDWLQEKEEFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGVDINRRLSPDDADFVDVLHTYTLSFGLSIGIRMPVGHIDIYPNGGDFQPGCGFNDVIGSFAYGTISEMVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSSRFKRGICLSCRKNRCNNIGYNAKKMRKKRNSKMYLKTRAGMPFKVYHYQLKVHMFSYNNSGDTQPTLYITLYGSNADSQNLPLEIVEKIELNATNTFLVYTEEDLGDLLKMRLTWEGVAHSWYNLWNEFRNYLSQPSNPSRELYIRRIRVKSGETQRKVTFCTQDPTKSSISPGQELWFHKCQDGWKMKNKTSPFVNLA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MRNTVFLLGFW ----CCCEEEEEEEE	11.41	27357545
14	Phosphorylation	LLGFWSVYCYFPAGS EEEEEEEEEEEECCC	3.95	27357545
16	Phosphorylation	GFWSVYCYFPAGSIT EEEEEEEEEECCCEE	8.56	27357545
23	Phosphorylation	YFPAGSITTLRPQGS EEECCCEEEECCCCC	22.83	27357545
65	N-linked_Glycosylation	DPEQEGCNLSLGDSK CHHHCCCCCCCCCHH	43.45	-
80	N-linked_Glycosylation	LLENCGFNMTAKTFF HHHHCCCCCCCEEEE	16.51	-
136	N-linked_Glycosylation	QLYTDAVNNTRVVGQ HHHHHHCCCCCCCHH	45.97	-
310	Phosphorylation	FKRGICLSCRKNRCN HCCCEEEECCCCCCC	13.89	-
359	N-linked_Glycosylation	KVHMFSYNNSGDTQP EEEEEEECCCCCCCC	34.69	-
393	N-linked_Glycosylation	IVEKIELNATNTFLV EEEEEEECCCCEEEE	31.74	-
491	N-linked_Glycosylation	QDGWKMKNKTSPFVN CCCCCCCCCCCCCCC	49.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LIPE_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LIPE_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LIPE_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LIPE_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.