LIMK2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LIMK2_MOUSE
• UniProt AC: O54785
• Protein Name: LIM domain kinase 2
• Gene Name: Limk2
• Organism: Mus musculus (Mouse).
• Sequence Length: 638
• Subcellular Localization: Cytoplasm.
• Protein Description: Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro..
• Protein Sequence: MAALAGDEAWRCRGCGTYVPLSQRLYRTANEAWHGSCFRCSECQESLTNWYYEKDGKLYCHKDYWAKFGEFCHGCSLLMTGPAMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQDQLPYSVTLISMPATTECRRGFSVTVESASSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAIKQTSQTLQLLIEHDPVPQRLDQLRLDARLPPHMQSTGHTLMLSTLDTKENQEGTLRRRSLRRSNSISKSPGPSSPKEPLLLSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSVDPFPWQQKVRFAKGISSGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPPVEKATTKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCKLEPESRPAFSKLEDSFEALSLFLGELAIPLPAELEDLDHTVSMEYGLTRDSPP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	CGTYVPLSQRLYRTA CCCEEEHHHHHHHHH	13.74	22006019
191	Phosphorylation	EVNRMHISPNNRNAI EECCCCCCCCCCCCC	13.59	25338131
210	Phosphorylation	RILEINGTPVRTLRV CEEEECCEECEEEEH	17.70	-
278	Phosphorylation	TKENQEGTLRRRSLR CCCCCCCHHHHHHHH	19.15	23140645
283	Phosphorylation	EGTLRRRSLRRSNSI CCHHHHHHHHHCCCC	25.15	-
287	Phosphorylation	RRRSLRRSNSISKSP HHHHHHHCCCCCCCC	28.61	21082442
289	Phosphorylation	RSLRRSNSISKSPGP HHHHHCCCCCCCCCC	29.50	22942356
291	Phosphorylation	LRRSNSISKSPGPSS HHHCCCCCCCCCCCC	27.23	26239621
293	Phosphorylation	RSNSISKSPGPSSPK HCCCCCCCCCCCCCC	28.44	21082442
297	Phosphorylation	ISKSPGPSSPKEPLL CCCCCCCCCCCCCEE	66.25	25266776
298	Phosphorylation	SKSPGPSSPKEPLLL CCCCCCCCCCCCEEE	43.03	22942356
306	Phosphorylation	PKEPLLLSRDISRSE CCCCEEECCCCCCCC	28.07	22345495
314	Phosphorylation	RDISRSESLRCSSSY CCCCCCCCCCCCCCC	23.51	27600695
322	Phosphorylation	LRCSSSYSQQIFRPC CCCCCCCHHHHCCCC	19.98	27600695
489	Phosphorylation	RPPVEKATTKKRTLR CCCCCCCCCCCCCCC	50.66	25338131
490	Phosphorylation	PPVEKATTKKRTLRK CCCCCCCCCCCCCCH	39.15	25338131
505	Phosphorylation	SDRKKRYTVVGNPYW HHCCCCEEEECCCCC	16.85	19553453

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
505	T	Phosphorylation	Kinase	ROCK1	P70335	Uniprot
505	T	Phosphorylation	Kinase	CDC42BP	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LIMK2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LIMK2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAXI_MOUSE	Pxn	physical	16399995
LIMK1_MOUSE	Limk1	physical	16399995

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.