LGUL_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LGUL_MOUSE
• UniProt AC: Q9CPU0
• Protein Name: Lactoylglutathione lyase
• Gene Name: Glo1
• Organism: Mus musculus (Mouse).
• Sequence Length: 184
• Protein Description: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis..
• Protein Sequence: MAEPQPASSGLTDETAFSCCSDPDPSTKDFLLQQTMLRIKDPKKSLDFYTRVLGLTLLQKLDFPAMKFSLYFLAYEDKNDIPKDKSEKTAWTFSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKIATII

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEPQPASS ------CCCCCCCCC	36.86	-
44	Acetylation	LRIKDPKKSLDFYTR HHCCCCCHHHHHHHH	62.73	22826441
44	Malonylation	LRIKDPKKSLDFYTR HHCCCCCHHHHHHHH	62.73	26320211
56	Phosphorylation	YTRVLGLTLLQKLDF HHHHHHHHHHHHCCC	24.51	-
60	Ubiquitination	LGLTLLQKLDFPAMK HHHHHHHHCCCCHHH	50.41	-
60	Acetylation	LGLTLLQKLDFPAMK HHHHHHHHCCCCHHH	50.41	22826441
88	Succinylation	IPKDKSEKTAWTFSR CCCCCCCCCCEEEEE	51.11	-
88	Ubiquitination	IPKDKSEKTAWTFSR CCCCCCCCCCEEEEE	51.11	-
88	Acetylation	IPKDKSEKTAWTFSR CCCCCCCCCCEEEEE	51.11	23806337
88	Succinylation	IPKDKSEKTAWTFSR CCCCCCCCCCEEEEE	51.11	23806337
96	Ubiquitination	TAWTFSRKATLELTH CCEEEEECEEEEEEE	44.52	-
107	Phosphorylation	ELTHNWGTEDDETQS EEEECCCCCCCCCHH	28.05	-
136	Phosphorylation	GIAVPDVYSACKRFE EEECHHHHHHHHHHH	9.64	17242355
137	Phosphorylation	IAVPDVYSACKRFEE EECHHHHHHHHHHHH	27.34	29472430
139	S-nitrosylation	VPDVYSACKRFEELG CHHHHHHHHHHHHHC	2.39	21278135
139	Glutathionylation	VPDVYSACKRFEELG CHHHHHHHHHHHHHC	2.39	24333276
139	S-palmitoylation	VPDVYSACKRFEELG CHHHHHHHHHHHHHC	2.39	28526873
139	S-glutathionyl cysteine	VPDVYSACKRFEELG CHHHHHHHHHHHHHC	2.39	-
140	Malonylation	PDVYSACKRFEELGV HHHHHHHHHHHHHCC	60.89	26320211
140	Ubiquitination	PDVYSACKRFEELGV HHHHHHHHHHHHHCC	60.89	-
140	Acetylation	PDVYSACKRFEELGV HHHHHHHHHHHHHCC	60.89	23201123
148	Ubiquitination	RFEELGVKFVKKPDD HHHHHCCEEEECCCC	42.51	-
148	Succinylation	RFEELGVKFVKKPDD HHHHHCCEEEECCCC	42.51	23806337
148	Succinylation	RFEELGVKFVKKPDD HHHHHCCEEEECCCC	42.51	-
148	Malonylation	RFEELGVKFVKKPDD HHHHHCCEEEECCCC	42.51	26320211
148	Acetylation	RFEELGVKFVKKPDD HHHHHCCEEEECCCC	42.51	22826441
151	Acetylation	ELGVKFVKKPDDGKM HHCCEEEECCCCCCE	62.82	23201123
152	Acetylation	LGVKFVKKPDDGKMK HCCEEEECCCCCCEE	48.67	22826441
159	Acetylation	KPDDGKMKGLAFIQD CCCCCCEEEEEEEEC	55.01	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LGUL_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
107	T	Phosphorylation	Phosphorylated at Thr-107 in the presence of CaMK2.	-
139	C	Glutathionylation	Glutathionylation at Cys-139 inhibits enzyme activity.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LGUL_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LGUL_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.