| UniProt ID | LGSN_HUMAN | |
|---|---|---|
| UniProt AC | Q5TDP6 | |
| Protein Name | Lengsin | |
| Gene Name | LGSN | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 509 | |
| Subcellular Localization | ||
| Protein Description | May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity).. | |
| Protein Sequence | MNNEEDLLQEDSTRDEGNETEANSMNTLRRTRKKVTKPYVCSTEVGETDMSNSNDCMRDSSQILTPPQLSSRMKHIRQAMAKNRLQFVRFEATDLHGVSRSKTIPAHFFQEKVSHGVCMPRGYLEVIPNPKDNEMNNIRATCFNSDIVLMPELSTFRVLPWADRTARVICDTFTVTGEPLLTSPRYIAKRQLSHLQASGFSLLSAFIYDFCIFGVPEILNSKIISFPALTFLNNHDQPFMQELVDGLYHTGANVESFSSSTRPGQMEISFLPEFGISSADNAFTLRTGVKEVARKYNYIASFFIETGFCDSGILSHSLWDVDRKKNMFCSTSGTEQLTITGKKWLAGLLKHSAALSCLMAPSVSCRKRYSKDRKDLKKSVPTTWGYNDNSCIFNIKCHGEKGTRIENKLGSATANPYLVLAATVAAGLDGLHSSNEVLAGPDESTDFYQVEPSEIPLKLEDALVALEEDQCLRQALGETFIRYFVAMKKYELENEEIAAERNKFLEYFI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Phosphorylation | EDLLQEDSTRDEGNE HHHHHCCCCCCCCCH | 25.29 | 28509920 | |
| 13 | Phosphorylation | DLLQEDSTRDEGNET HHHHCCCCCCCCCHH | 55.23 | 28509920 | |
| 123 | Phosphorylation | GVCMPRGYLEVIPNP CEECCCCEEEECCCC | 10.85 | - | |
| 172 (in isoform 2) | Phosphorylation | - | 19.45 | 28450419 | |
| 174 (in isoform 2) | Phosphorylation | - | 21.17 | 28450419 | |
| 176 (in isoform 2) | Phosphorylation | - | 32.54 | 28450419 | |
| 178 (in isoform 2) | Phosphorylation | - | 24.33 | 28450419 | |
| 181 (in isoform 2) | Phosphorylation | - | 6.97 | 28450419 | |
| 284 | Phosphorylation | SSADNAFTLRTGVKE CCCCCCEECCCCHHH | 16.96 | 24719451 | |
| 369 | Phosphorylation | SVSCRKRYSKDRKDL CHHHHHHHCCCHHHH | 24.09 | 22468782 | |
| 413 | Phosphorylation | ENKLGSATANPYLVL CCCCCCCCCCHHHHH | 28.76 | 22210691 | |
| 445 | Phosphorylation | LAGPDESTDFYQVEP ECCCCCCCCCEECCC | 28.25 | 22210691 | |
| 453 | Phosphorylation | DFYQVEPSEIPLKLE CCEECCCHHCCCCHH | 34.35 | 22210691 | |
| 483 | Phosphorylation | LGETFIRYFVAMKKY HHHHHHHHHHHHHHH | 9.51 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LGSN_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LGSN_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LGSN_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of LGSN_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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