| UniProt ID | LGI1_HUMAN | |
|---|---|---|
| UniProt AC | O95970 | |
| Protein Name | Leucine-rich glioma-inactivated protein 1 | |
| Gene Name | LGI1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 557 | |
| Subcellular Localization | Secreted . Cell junction, synapse. Isoform 1 but not isoform 2 is secreted. Isoform 1 is enriched in the Golgi apparatus while isoform 2 accumulates in the endoplasmic reticulum. | |
| Protein Description | Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival.. | |
| Protein Sequence | MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 21 | Phosphorylation | IPLKRIAYFLCLLSA HHHHHHHHHHHHHHH | 8.50 | 19835603 | |
| 27 | Phosphorylation | AYFLCLLSALLLTEG HHHHHHHHHHHHHCC | 12.15 | 19835603 | |
| 32 | Phosphorylation | LLSALLLTEGKKPAK HHHHHHHHCCCCCCC | 42.53 | 19835603 | |
| 129 | Phosphorylation | IENNNIKSISRHTFR EECCCCCEEEHHHHH | 23.23 | 29514088 | |
| 131 | Phosphorylation | NNNIKSISRHTFRGL CCCCCEEEHHHHHHH | 25.71 | 29514088 | |
| 134 | Phosphorylation | IKSISRHTFRGLKSL CCEEEHHHHHHHHHH | 17.58 | 29514088 | |
| 160 | Ubiquitination | TLPKDIFKGLDSLTN CCCHHHHCCHHHCCC | 59.92 | - | |
| 192 | N-linked_Glycosylation | VEWLGHTNATVEDIY HHHHCCCCCCHHHCC | 28.12 | UniProtKB CARBOHYD | |
| 277 | N-linked_Glycosylation | KTFRNYDNITGTSTV HHCCCCCCCCCCCEE | 24.30 | UniProtKB CARBOHYD | |
| 422 | N-linked_Glycosylation | KATQLFTNQTDIPNM HHHHHHCCCCCCCCH | 35.11 | UniProtKB CARBOHYD | |
| 464 | Phosphorylation | VMKWGGSSFQDIQRM CEECCCCCHHHHHHC | 30.15 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LGI1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LGI1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LGI1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of LGI1_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 600512 | Epilepsy, familial temporal lobe, 1 (ETL1) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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