dbPTM

LFG2_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LFG2_RAT
UniProt AC	O88407
Protein Name	Protein lifeguard 2
Gene Name	Faim2
Organism	Rattus norvegicus (Rat).
Sequence Length	316
Subcellular Localization	Cell membrane Multi-pass membrane protein . Membrane raft. Cell junction, synapse, postsynaptic cell membrane .
Protein Description	Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development (By similarity)..
Protein Sequence	MTQGKLSVANKAPGTEGQQQANGEKKDAPAVPSAPPSYEEATSGEGLKAGAFPQGPTAVPLHPSWAYVDPSSSSGYEGGFPAGHHELFSTFSWDDQKVRQLFIRKVYTILLVQLLVTLAVVALFTFCDVVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTIFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTIFSFQTKFDFTSCHGVLFVLLMTLFFSGLLLAILLPFQYVPWLHAVYAVLGAGVFTLFLAFDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Ubiquitination	GKLSVANKAPGTEGQ CCCCCCCCCCCCCCC	46.34	-
25	Ubiquitination	QQQANGEKKDAPAVP CHHCCCCCCCCCCCC	58.30	-
26	Ubiquitination	QQANGEKKDAPAVPS HHCCCCCCCCCCCCC	55.62	-
37	Phosphorylation	AVPSAPPSYEEATSG CCCCCCCCHHCCCCC	44.08	22276854
38	Phosphorylation	VPSAPPSYEEATSGE CCCCCCCHHCCCCCC	24.46	22276854
42	Phosphorylation	PPSYEEATSGEGLKA CCCHHCCCCCCCCCC	40.31	22276854
191	N-linked_Glycosylation	GMLSSYYNTTSVLLC HHHHHHCCHHHHHHH	28.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LFG2_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LFG2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LFG2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of LFG2_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LFG2_RAT

Related Literatures of Post-Translational Modification