LFG2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LFG2_HUMAN
• UniProt AC: Q9BWQ8
• Protein Name: Protein lifeguard 2
• Gene Name: FAIM2
• Organism: Homo sapiens (Human).
• Sequence Length: 316
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Membrane raft . Cell junction, synapse, postsynaptic cell membrane.
• Protein Description: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development..
• Protein Sequence: MTQGKLSVANKAPGTEGQQQVHGEKKEAPAVPSAPPSYEEATSGEGMKAGAFPPAPTAVPLHPSWAYVDPSSSSSYDNGFPTGDHELFTTFSWDDQKVRRVFVRKVYTILLIQLLVTLAVVALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTVFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTVFSFQTKFDFTSCQGVLFVLLMTLFFSGLILAILLPFQYVPWLHAVYAALGAGVFTLFLALDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MTQGKLSVANKA ---CCCCCCCCCCCC	27.98	30230243
11	Acetylation	GKLSVANKAPGTEGQ CCCCCCCCCCCCCCC	46.34	7964571
11	Ubiquitination	GKLSVANKAPGTEGQ CCCCCCCCCCCCCCC	46.34	32142685
25	Ubiquitination	QQQVHGEKKEAPAVP CCCCCCCCCCCCCCC	61.58	30230243
26	Ubiquitination	QQVHGEKKEAPAVPS CCCCCCCCCCCCCCC	55.60	30230243
33	Phosphorylation	KEAPAVPSAPPSYEE CCCCCCCCCCCCCCC	46.97	-
38	Phosphorylation	VPSAPPSYEEATSGE CCCCCCCCCCCCCCC	24.46	25884760
42	Phosphorylation	PPSYEEATSGEGMKA CCCCCCCCCCCCCCC	40.31	-
43	Phosphorylation	PSYEEATSGEGMKAG CCCCCCCCCCCCCCC	41.73	19690332
191	N-linked_Glycosylation	GMLSSYYNTTSVLLC HHHHHHCCHHHHHHH	28.75	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LFG2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LFG2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LFG2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNR6_HUMAN	FAS	physical	10535980
RO52_HUMAN	TRIM21	physical	26398169

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.