LEU11_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LEU11_ARATH
• UniProt AC: Q9LPR4
• Protein Name: 2-isopropylmalate synthase 1, chloroplastic
• Gene Name: IPMS1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 631
• Subcellular Localization: Plastid, chloroplast .
• Protein Description: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Involved in Leu biosynthesis, but do not participate in the chain elongation of glucosinolates..
• Protein Sequence: MASSLLRNPNLYSSTTITTTSFLPTFSSKPTPISSSFRFQPSHHRSISLRSQTLRLSCSISDPSPLPPHTPRRPRPEYIPNRISDPNYVRVFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEAGFPAASKDDFEAVKTIAETVGNTVDENGYVPVICGLSRCNKKDIERAWDAVKYAKRPRIHTFIATSDIHLEYKLKKTKAEVIEIARSMVRFARSLGCEDVEFSPEDAGRSEREYLYEILGEVIKAGATTLNIPDTVGITLPSEFGQLITDLKANTPGIENVVISTHCQNDLGLSTANTLSGAHAGARQMEVTINGIGERAGNASLEEVVMAIKCRGDHVLGGLFTGIDTRHIVMTSKMVEEYTGMQTQPHKAIVGANAFAHESGIHQDGMLKHKGTYEIICPEEIGLERSNDAGIVLGKLSGRHALKDRLTELGYQLDDEQLSTIFWRFKTVAEQKKRVTDADIIALVSDEVFQPEAVWKLLDIQITCGTLGLSTATVKLADADGKEHVACSIGTGPVDSAYKAVDLIVKEPATLLEYSMNAVTEGIDAIATTRVLIRGSNKYSSTNAITGEEVQRTFSGTGAGMDIVVSSVKAYVGALNKMMDFKENSATKIPSQKNRVAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	HRSISLRSQTLRLSC CCCEECCCCEEEEEE	32.58	23172892
53	Phosphorylation	SISLRSQTLRLSCSI CEECCCCEEEEEEEC	18.32	23172892
57	Phosphorylation	RSQTLRLSCSISDPS CCCEEEEEEECCCCC	10.21	23172892
59	Phosphorylation	QTLRLSCSISDPSPL CEEEEEEECCCCCCC	23.04	23172892
61	Phosphorylation	LRLSCSISDPSPLPP EEEEEECCCCCCCCC	27.46	23172892
64	Phosphorylation	SCSISDPSPLPPHTP EEECCCCCCCCCCCC	44.02	23172892
70	Phosphorylation	PSPLPPHTPRRPRPE CCCCCCCCCCCCCCC	25.02	23172892
102	Phosphorylation	TLRDGEQSPGATLTS CCCCCCCCCCCCCCC	22.46	25561503
430	Phosphorylation	GIVLGKLSGRHALKD CEEEEEECCHHHHHH	36.95	24243849

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LEU11_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LEU11_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LEU11_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of LEU11_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.