dbPTM

LEG1_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LEG1_RAT
UniProt AC	P11762
Protein Name	Galectin-1
Gene Name	Lgals1
Organism	Rattus norvegicus (Rat).
Sequence Length	135
Subcellular Localization	Secreted, extracellular space, extracellular matrix .
Protein Description	Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis..
Protein Sequence	MACGLVASNLNLKPGECLKVRGELAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDDGTWGTEQRETAFPFQPGSITEVCITFDQADLTIKLPDGHEFKFPNRLNMEAINYMAADGDFKIKCVAFE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MACGLVASN ------CCCCCEEEC	8.97	-
13	Acetylation	VASNLNLKPGECLKV EEECCCCCCCCEEEE	50.32	-
19	Acetylation	LKPGECLKVRGELAP CCCCCEEEECCEECC	41.36	22902405
29	Acetylation	GELAPDAKSFVLNLG CEECCCCCEEEEEEC	52.38	22902405
30	Phosphorylation	ELAPDAKSFVLNLGK EECCCCCEEEEEECC	23.47	25532521
64	Acetylation	NTIVCNSKDDGTWGT CEEEEECCCCCCCCC	45.94	26302492
108	Acetylation	LPDGHEFKFPNRLNM CCCCCCEECCCCCCH	57.85	22902405
108	Succinylation	LPDGHEFKFPNRLNM CCCCCCEECCCCCCH	57.85	-
108	Succinylation	LPDGHEFKFPNRLNM CCCCCCEECCCCCCH	57.85	-
128	Acetylation	MAADGDFKIKCVAFE HCCCCCCEEEEEEEC	46.10	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LEG1_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LEG1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LEG1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of LEG1_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LEG1_RAT

Related Literatures of Post-Translational Modification