LDHB_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LDHB_RAT
• UniProt AC: P42123
• Protein Name: L-lactate dehydrogenase B chain
• Gene Name: Ldhb
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 334
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MATLKEKLIAPVADDETAVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCTIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVDSAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLRKSADTLWDIQKDLKDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATLKEKLI ------CCCHHHHHC	22.95	-
5	Acetylation	---MATLKEKLIAPV ---CCCHHHHHCCCC	48.74	-
7	Acetylation	-MATLKEKLIAPVAD -CCCHHHHHCCCCCC	43.54	22902405
7	Ubiquitination	-MATLKEKLIAPVAD -CCCHHHHHCCCCCC	43.54	-
17	Phosphorylation	APVADDETAVPNNKI CCCCCCCCCCCCCEE	39.69	22673903
44	Phosphorylation	AISILGKSLADELAL HHHHHCHHHHHHHHH	27.30	22673903
58	"N6,N6-dimethyllysine"	LVDVLEDKLKGEMMD HHHHHHHHHCCCCEE	42.60	-
58	Acetylation	LVDVLEDKLKGEMMD HHHHHHHHHCCCCEE	42.60	22902405
58	Methylation	LVDVLEDKLKGEMMD HHHHHHHHHCCCCEE	42.60	12692561
60	"N6,N6-dimethyllysine"	DVLEDKLKGEMMDLQ HHHHHHHCCCCEECC	59.57	-
60	Acetylation	DVLEDKLKGEMMDLQ HHHHHHHCCCCEECC	59.57	22902405
60	Methylation	DVLEDKLKGEMMDLQ HHHHHHHCCCCEECC	59.57	12692561
82	Acetylation	TPKIVADKDYSVTAN CCCEEECCCCEEECC	49.15	22902405
84	Phosphorylation	KIVADKDYSVTANSK CEEECCCCEEECCCE	15.69	-
85	Phosphorylation	IVADKDYSVTANSKI EEECCCCEEECCCEE	24.11	29779826
91	Acetylation	YSVTANSKIVVVTAG CEEECCCEEEEEEEC	39.05	26302492
119	Acetylation	QRNVNVFKFIIPQIV HHHHCCHHHHHHHHH	31.22	22902405
127	Acetylation	FIIPQIVKYSPDCTI HHHHHHHHCCCCCEE	41.46	-
233	Acetylation	ENWKEVHKMVVDSAY CCHHHHHHHHHHHHH	38.27	22902405
240	Phosphorylation	KMVVDSAYEVIKLKG HHHHHHHHHHHHCCC	18.06	-
244	Acetylation	DSAYEVIKLKGYTNW HHHHHHHHCCCCCCC	49.69	22902405
244	Ubiquitination	DSAYEVIKLKGYTNW HHHHHHHHCCCCCCC	49.69	-
308	Acetylation	LTSVINQKLKDDEVA HHHHHCHHCCCCHHH	53.68	22902405
308	Ubiquitination	LTSVINQKLKDDEVA HHHHHCHHCCCCHHH	53.68	-
310	Acetylation	SVINQKLKDDEVAQL HHHCHHCCCCHHHHH	70.89	22902405
310	Ubiquitination	SVINQKLKDDEVAQL HHHCHHCCCCHHHHH	70.89	-
319	Acetylation	DEVAQLRKSADTLWD CHHHHHHHHHHHHHH	59.60	22902405
329	Acetylation	DTLWDIQKDLKDL-- HHHHHHHHHHHCC--	66.42	22902405
329	Ubiquitination	DTLWDIQKDLKDL-- HHHHHHHHHHHCC--	66.42	-
332	Acetylation	WDIQKDLKDL----- HHHHHHHHCC-----	68.09	22902405
332	Ubiquitination	WDIQKDLKDL----- HHHHHHHHCC-----	68.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LDHB_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LDHB_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LDHB_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of LDHB_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.