LBR_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LBR_RAT
• UniProt AC: O08984
• Protein Name: Lamin-B receptor
• Gene Name: Lbr
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 620
• Subcellular Localization: Nucleus inner membrane; Multi-pass membrane protein.
• Protein Description: Anchors the lamina and the heterochromatin to the inner nuclear membrane..
• Protein Sequence: MPGRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKESDIKPLKSFKQRKSGSTSSSPSRRRSSRSRSRSRSRSPGRAPKGSRRSVSASYQADAKEKEMRREILQVKLTPLVLKPFANSVSVYNGEPEHMEKSATPPKNKQERVILSTEDSYIATQYSLRPRREEVKPKHRVRGTNLVTRGPVPLGTFQVTTPQRRDLEFGGVPGALLIMLGLPACVFLLLLQCAQKDPGLLQFPPPLPALRELWEARVCGVYLLWFFLQALFSLLPVGKVVEGTPLVDGRRLKYRLNGLYAFILTSAAVGTAVFWDIELYYLYTHFLQFALAAIVFSVVLSVYLYARSLKVPRDELSPASSGNAVYDFFIGRELNPRIGAFDLKFFCELRPGLIGWVVINLVMLLAEMKVQERSAPSLAMTLVNSFQLLYVVDALWFEEALLTTMDIIHDGFGFMLAFGDLVWVPFTYSLQAFYLVNHPQDLSWPLTSVIIALKLCGYVIFRCANSQKNAFRKNPTDPKLAHLKTIPTSTWKSLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYVIYFTALLIHREARDEHQCRRKYGLAWEKYCQRVPYRIFPYIY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Acetylation	ELKESDIKPLKSFKQ EEEHHHCCCCHHHCC	49.65	22902405
59	Phosphorylation	SDIKPLKSFKQRKSG HHCCCCHHHCCCCCC	45.41	26022182
67	Phosphorylation	FKQRKSGSTSSSPSR HCCCCCCCCCCCHHH	32.01	25403869
68	Phosphorylation	KQRKSGSTSSSPSRR CCCCCCCCCCCHHHH	35.83	25403869
69	Phosphorylation	QRKSGSTSSSPSRRR CCCCCCCCCCHHHHH	30.43	25403869
70	Phosphorylation	RKSGSTSSSPSRRRS CCCCCCCCCHHHHHH	46.48	25403869
71	Phosphorylation	KSGSTSSSPSRRRSS CCCCCCCCHHHHHHH	27.02	25403869
73	Phosphorylation	GSTSSSPSRRRSSRS CCCCCCHHHHHHHCH	40.13	25403869
86	Phosphorylation	RSRSRSRSRSPGRAP CHHHCCCCCCCCCCC	38.05	-
88	Phosphorylation	RSRSRSRSPGRAPKG HHCCCCCCCCCCCCC	32.71	-
96	O-linked_Glycosylation	PGRAPKGSRRSVSAS CCCCCCCCCCCCCHH	30.55	12438562
96	Phosphorylation	PGRAPKGSRRSVSAS CCCCCCCCCCCCCHH	30.55	-
99	Phosphorylation	APKGSRRSVSASYQA CCCCCCCCCCHHHHC	21.22	22108457
101	Phosphorylation	KGSRRSVSASYQADA CCCCCCCCHHHHCCH	16.85	27097102
103	Phosphorylation	SRRSVSASYQADAKE CCCCCCHHHHCCHHH	15.40	22673903
104	Phosphorylation	RRSVSASYQADAKEK CCCCCHHHHCCHHHH	13.87	22673903
123	Phosphorylation	EILQVKLTPLVLKPF HHHHHCCHHHHHHCC	14.62	22673903
133	Phosphorylation	VLKPFANSVSVYNGE HHHCCCCEEEEECCC	16.61	-
149	Phosphorylation	EHMEKSATPPKNKQE HHCCCCCCCCCCCCC	47.41	25403869
205	Phosphorylation	PLGTFQVTTPQRRDL CCCEEEECCCCCCCC	23.21	-
599	Acetylation	DEHQCRRKYGLAWEK CHHHHHHHHCCHHHH	25.07	-
606	Acetylation	KYGLAWEKYCQRVPY HHCCHHHHHHHHCCC	40.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
71	S	Phosphorylation	Kinase	CDK1	P39951	Uniprot
86	S	Phosphorylation	Kinase	CDK1	P39951	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LBR_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LBR_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of LBR_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

O-linked Glycosylation

"Mapping sites of O-GlcNAc modification using affinity tags for serineand threonine post-translational modifications.";
Wells L., Vosseller K., Cole R.N., Cronshaw J.M., Matunis M.J.,Hart G.W.;
Mol. Cell. Proteomics 1:791-804(2002).
Cited for: GLYCOSYLATION AT SER-96, AND MASS SPECTROMETRY.
PubMed: 12438562