LAYN_HUMAN - dbPTM
LAYN_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LAYN_HUMAN
UniProt AC Q6UX15
Protein Name Layilin
Gene Name LAYN
Organism Homo sapiens (Human).
Sequence Length 382
Subcellular Localization Membrane
Single-pass type I membrane protein . Colocalizes with TLN1 at the membrane ruffles..
Protein Description Receptor for hyaluronate..
Protein Sequence MRPGTALQAVLLAVLLVGLRAATGRLLSASDLDLRGGQPVCRGGTQRPCYKVIYFHDTSRRLNFEEAKEACRRDGGQLVSIESEDEQKLIEKFIENLLPSDGDFWIGLRRREEKQSNSTACQDLYAWTDGSISQFRNWYVDEPSCGSEVCVVMYHQPSAPAGIGGPYMFQWNDDRCNMKNNFICKYSDEKPAVPSREAEGEETELTTPVLPEETQEEDAKKTFKESREAALNLAYILIPSIPLLLLLVVTTVVCWVWICRKRKREQPDPSTKKQHTIWPSPHQGNSPDLEVYNVIRKQSEADLAETRPDLKNISFRVCSGEATPDDMSCDYDNMAVNPSESGFVTLVSVESGFVTNDIYEFSPDQMGRSKESGWVENEIYGY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3 (in isoform 3)Phosphorylation-43.0924114839
4 (in isoform 3)Phosphorylation-17.1624114839
8 (in isoform 3)Phosphorylation-27.2824114839
23 (in isoform 2)Phosphorylation-23.1129083192
28 (in isoform 2)Phosphorylation-30.2529083192
37 (in isoform 2)Phosphorylation-23.3729083192
42 (in isoform 2)Phosphorylation-46.9729083192
108MethylationDGDFWIGLRRREEKQ
CCCCEEEEECCHHHH		2.57-
117N-linked_GlycosylationRREEKQSNSTACQDL
CCHHHHCCCCCCHHH		40.67UniProtKB CARBOHYD
186PhosphorylationKNNFICKYSDEKPAV
CCCEEEEECCCCCCC		19.5527174698
187PhosphorylationNNFICKYSDEKPAVP
CCEEEEECCCCCCCC		25.4527174698
195PhosphorylationDEKPAVPSREAEGEE
CCCCCCCCCCCCCCC		35.8327174698
195O-linked_GlycosylationDEKPAVPSREAEGEE
CCCCCCCCCCCCCCC		35.8355830697
206O-linked_GlycosylationEGEETELTTPVLPEE
CCCCCEECCCCCCHH		23.87OGP
261MethylationCWVWICRKRKREQPD
HHHHHHHHHCCCCCC		58.8423644510
280PhosphorylationKQHTIWPSPHQGNSP
CCCCCCCCCCCCCCC		21.7327642862
286PhosphorylationPSPHQGNSPDLEVYN
CCCCCCCCCCHHHHH		26.9822617229
291 (in isoform 2)Phosphorylation-5.6824719451
292PhosphorylationNSPDLEVYNVIRKQS
CCCCHHHHHHHHHHC		8.3725884760
299PhosphorylationYNVIRKQSEADLAET
HHHHHHHCHHHHHHH		37.4730266825
306 (in isoform 2)Phosphorylation-41.7324719451
306PhosphorylationSEADLAETRPDLKNI
CHHHHHHHCCCHHCC		41.7329978859
311UbiquitinationAETRPDLKNISFRVC
HHHCCCHHCCEEEEE		60.66-
314PhosphorylationRPDLKNISFRVCSGE
CCCHHCCEEEEECCC		19.1824719451
359PhosphorylationGFVTNDIYEFSPDQM
CCCCCCCEECCHHHC		17.4925884760
380PhosphorylationGWVENEIYGY-----
CCCCCCCCCC-----		12.2825884760
382PhosphorylationVENEIYGY-------
CCCCCCCC-------		9.8225348954
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LAYN_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LAYN_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LAYN_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LAYN_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LAYN_HUMAN

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Related Literatures of Post-Translational Modification

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