dbPTM

LAS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LAS2_HUMAN
UniProt AC	Q8IYD9
Protein Name	Lung adenoma susceptibility protein 2
Gene Name	LAS2
Organism	Homo sapiens (Human).
Sequence Length	372
Subcellular Localization	Secreted .
Protein Description	Might play a role in cell proliferation..
Protein Sequence	MAKSKTKHRLCSQESSVSALLASCTLSGSNSSNSDGSFHYKDKLYRSASQALQAYIDDFDLGQIYPGASTGKINIDEDFTNMSQFCNYIYKPNNAFENLDHKKHSNFISCRRHTVNDIDSMSLTTDDLLRLPADGSFSYTYVGPSHRTSKKNKKCRGRLGSLDIEKNPHFQGPYTSMGKDNFVTPVIRSNINGKQCGDKIELLILKAKRNLEQCTEELPKSMKKDDSPCSLDKLEADRSWENIPVTFKSPVPVNSDDSPQQTSRAKSAKGVLEDFLNNDNQSCTLSGGKHHGPVEALKQMLFNLQAVQERFNQNKTTDPKEEIKQVSEDDFSKLQLKESMIPITRSLQKALHHLSRLRDLVDDTNGERSPKM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
122	Phosphorylation	VNDIDSMSLTTDDLL CCCCHHCCCCHHHHC	26.90	-
161	Phosphorylation	KCRGRLGSLDIEKNP CCCCCCCCCCCCCCC	27.71	25850435
224	Acetylation	ELPKSMKKDDSPCSL HHCHHHCCCCCCCCH	59.11	19825761
233	Ubiquitination	DSPCSLDKLEADRSW CCCCCHHHHHHCCCC	54.22	-
289	Ubiquitination	SCTLSGGKHHGPVEA CEEECCCCCCCHHHH	35.63	-
333	Ubiquitination	VSEDDFSKLQLKESM CCCCHHHHHHHHHHH	40.00	-
339	Phosphorylation	SKLQLKESMIPITRS HHHHHHHHHCHHHHH	22.03	27794612
346	Phosphorylation	SMIPITRSLQKALHH HHCHHHHHHHHHHHH	26.88	-
355	Phosphorylation	QKALHHLSRLRDLVD HHHHHHHHHHHHHHC	25.55	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LAS2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LAS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LAS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
KDM1A_HUMAN	KDM1A	physical	23455924

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LAS2_HUMAN

Related Literatures of Post-Translational Modification