LARP4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LARP4_MOUSE
• UniProt AC: Q8BWW4
• Protein Name: La-related protein 4
• Gene Name: Larp4
• Organism: Mus musculus (Mouse).
• Sequence Length: 719
• Subcellular Localization: Cytoplasm, Stress granule . Cytoplasm, cytosol . Localized throughout the cytosol. Partially localized in stress granules in response to arsenite treatment.
• Protein Description: RNA binding protein that binds to the poly-A tract of mRNA molecules. Associates with the 40S ribosomal subunit and with polysomes. Plays a role in the regulation of mRNA translation. Plays a role in the regulation of cell morphology and cytoskeletal organization..
• Protein Sequence: MLLFVEVTSKGTGLNPNAKVWQEIPSGNPDGTPVTEPSWHETAATSGSHPEGHTELSEDMCKEYEVMYSPSCETTRNTADVEESADGMILGPEDLSYQLYDVSGESSSAISTEDLKECLKKQLEFCFSRENLSKDLYLISQMDSDQFVPIWTVANMEEIKKLTTNTDLILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPVEEVKALFKNENCPKVISCEFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMARIKAINTFFAKNGYRLMDSSMYTQPIQTPTQYPSPVFMQPVYNPQQYSVYSLVPQSWSPSPAPYFETPLAPFPNGSFVDGFSSPGSYKTNAAAMNMGRPFPKNRVKPHFRSSSGSEHSTEGSVSLGDGPLSRSSSRIFLSERHNPTVTGQQEQTYLPKEAPILQMEQNGDFGRGRRTLFRGRRRRDDDRIPRPQPAATEAKAPTPKFDLLATNFPPLPGSSSRVPDELGLENRMSDVVKGVCREKDSEDVRVSCPVPAEDGQTDCTSAPLSISPSPPCTAEPPVLSTTQQEQDQMEDSAVPKDTLNPVAVPVSSPTATKPSPANTASPCTSNINPPRAVALQEPRKLSYAEVCQKPPKEPSPVLVQPLRELRSNAVSPTRNEENGAPEKPVEKPHEKPETRASKDHSGFRGNTIPRGAAGKIREQRRQFSHRATPQGVTRRNGKEQYVPPRSPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLLFVEVT -------CEEEEEEE	7.09	-
54	Phosphorylation	GSHPEGHTELSEDMC CCCCCCCCCCCHHHH	49.86	25367039
57	Phosphorylation	PEGHTELSEDMCKEY CCCCCCCCHHHHHHC	25.89	25367039
64	Phosphorylation	SEDMCKEYEVMYSPS CHHHHHHCEEEECCC	10.18	25619855
68	Phosphorylation	CKEYEVMYSPSCETT HHHCEEEECCCCCCC	23.70	25619855
69	Phosphorylation	KEYEVMYSPSCETTR HHCEEEECCCCCCCC	7.70	25521595
71	Phosphorylation	YEVMYSPSCETTRNT CEEEECCCCCCCCCC	20.74	25619855
74	Phosphorylation	MYSPSCETTRNTADV EECCCCCCCCCCCCH	35.07	25619855
75	Phosphorylation	YSPSCETTRNTADVE ECCCCCCCCCCCCHH	10.30	25619855
128	Phosphorylation	KQLEFCFSRENLSKD HHHHHHCCCCCCCCC	39.61	20139300
134	Ubiquitination	FSRENLSKDLYLISQ CCCCCCCCCEEEEEC	55.72	-
161	Ubiquitination	ANMEEIKKLTTNTDL ECHHHHHHHCCCHHH	57.64	-
184	Ubiquitination	PMVQVDEKGEKVRPS CCEEECCCCCCCCCC	68.83	-
187	Acetylation	QVDEKGEKVRPSHKR EECCCCCCCCCCCCE	52.81	19859195
212	Ubiquitination	TTPVEEVKALFKNEN CCCHHHHHHHHCCCC	42.52	-
216	Acetylation	EEVKALFKNENCPKV HHHHHHHCCCCCCCE	65.29	22826441
276	Ubiquitination	AINTFFAKNGYRLMD HHHHHHHHCCEEECC	45.83	-
321	Phosphorylation	VYSLVPQSWSPSPAP EEEECCCCCCCCCCC	24.37	22807455
363	Methylation	AAAMNMGRPFPKNRV HHHHHCCCCCCCCCC	20.93	-
376	Phosphorylation	RVKPHFRSSSGSEHS CCCCCCCCCCCCCCC	28.10	21082442
377	Phosphorylation	VKPHFRSSSGSEHST CCCCCCCCCCCCCCC	34.17	21082442
378	Phosphorylation	KPHFRSSSGSEHSTE CCCCCCCCCCCCCCC	47.81	22942356
380	Phosphorylation	HFRSSSGSEHSTEGS CCCCCCCCCCCCCCC	33.80	22942356
383	Phosphorylation	SSSGSEHSTEGSVSL CCCCCCCCCCCCCCC	24.89	22942356
384	Phosphorylation	SSGSEHSTEGSVSLG CCCCCCCCCCCCCCC	46.39	21082442
387	Phosphorylation	SEHSTEGSVSLGDGP CCCCCCCCCCCCCCC	11.42	22942356
389	Phosphorylation	HSTEGSVSLGDGPLS CCCCCCCCCCCCCCC	28.47	25619855
396	Phosphorylation	SLGDGPLSRSSSRIF CCCCCCCCCCCCCEE	33.00	21082442
398	Phosphorylation	GDGPLSRSSSRIFLS CCCCCCCCCCCEEEE	29.32	25266776
399	Phosphorylation	DGPLSRSSSRIFLSE CCCCCCCCCCEEEEC	23.64	25266776
400	Phosphorylation	GPLSRSSSRIFLSER CCCCCCCCCEEEECC	30.55	22942356
411	Phosphorylation	LSERHNPTVTGQQEQ EECCCCCCCCCCEEE	35.70	23608596
419	Phosphorylation	VTGQQEQTYLPKEAP CCCCEEECCCCCCCC	26.69	25367039
420	Phosphorylation	TGQQEQTYLPKEAPI CCCEEECCCCCCCCE	22.24	24224561
423	Ubiquitination	QEQTYLPKEAPILQM EEECCCCCCCCEEEE	65.00	-
438	Methylation	EQNGDFGRGRRTLFR ECCCCCCCCCCHHHC	35.12	12019501
440	Methylation	NGDFGRGRRTLFRGR CCCCCCCCCHHHCCC	27.35	16187579
463	Phosphorylation	PRPQPAATEAKAPTP CCCCCCCCCCCCCCC	38.28	25777480
469	Phosphorylation	ATEAKAPTPKFDLLA CCCCCCCCCCCCEEE	43.93	26643407
477	Phosphorylation	PKFDLLATNFPPLPG CCCCEEECCCCCCCC	37.04	23984901
500	Phosphorylation	LGLENRMSDVVKGVC HCCCHHHHHHHHHHH	24.82	26643407
504	Ubiquitination	NRMSDVVKGVCREKD HHHHHHHHHHHCCCC	45.54	-
518	Phosphorylation	DSEDVRVSCPVPAED CCCCCEEECCEECCC	11.35	20469934
528	Phosphorylation	VPAEDGQTDCTSAPL EECCCCCCCCCCCCC	38.27	23140645
531	Phosphorylation	EDGQTDCTSAPLSIS CCCCCCCCCCCCEEC	30.63	23140645
532	Phosphorylation	DGQTDCTSAPLSISP CCCCCCCCCCCEECC	33.93	23140645
536	Phosphorylation	DCTSAPLSISPSPPC CCCCCCCEECCCCCC	21.69	20469934
538	Phosphorylation	TSAPLSISPSPPCTA CCCCCEECCCCCCCC	18.89	23140645
540	Phosphorylation	APLSISPSPPCTAEP CCCEECCCCCCCCCC	34.38	23140645
544	Phosphorylation	ISPSPPCTAEPPVLS ECCCCCCCCCCCCCC	39.57	23140645
551	Phosphorylation	TAEPPVLSTTQQEQD CCCCCCCCCCHHHHH	29.64	23140645
552	Phosphorylation	AEPPVLSTTQQEQDQ CCCCCCCCCHHHHHH	25.18	23140645
553	Phosphorylation	EPPVLSTTQQEQDQM CCCCCCCCHHHHHHC	25.53	23140645
563	Phosphorylation	EQDQMEDSAVPKDTL HHHHCCCCCCCCCCC	20.19	23140645
569	Phosphorylation	DSAVPKDTLNPVAVP CCCCCCCCCCCCEEE	34.26	25619855
578	Phosphorylation	NPVAVPVSSPTATKP CCCEEECCCCCCCCC	25.24	25521595
579	Phosphorylation	PVAVPVSSPTATKPS CCEEECCCCCCCCCC	26.89	25521595
581	Phosphorylation	AVPVSSPTATKPSPA EEECCCCCCCCCCCC	49.24	25521595
583	Phosphorylation	PVSSPTATKPSPANT ECCCCCCCCCCCCCC	46.06	22942356
586	Phosphorylation	SPTATKPSPANTASP CCCCCCCCCCCCCCC	37.89	22942356
590	Phosphorylation	TKPSPANTASPCTSN CCCCCCCCCCCCCCC	30.53	22942356
592	Phosphorylation	PSPANTASPCTSNIN CCCCCCCCCCCCCCC	20.61	22942356
595	Phosphorylation	ANTASPCTSNINPPR CCCCCCCCCCCCCCC	28.35	25619855
596	Phosphorylation	NTASPCTSNINPPRA CCCCCCCCCCCCCCC	42.29	20469934
613	Phosphorylation	LQEPRKLSYAEVCQK CCCCCCCCHHHHHCC	25.90	23984901
614	Phosphorylation	QEPRKLSYAEVCQKP CCCCCCCHHHHHCCC	19.74	23984901
620	Acetylation	SYAEVCQKPPKEPSP CHHHHHCCCCCCCCC	59.15	22826441
626	Phosphorylation	QKPPKEPSPVLVQPL CCCCCCCCCCCCHHH	28.82	26824392
638	Phosphorylation	QPLRELRSNAVSPTR HHHHHHHCCCCCCCC	41.59	23684622
642	Phosphorylation	ELRSNAVSPTRNEEN HHHCCCCCCCCCCCC	20.38	26824392
644	Phosphorylation	RSNAVSPTRNEENGA HCCCCCCCCCCCCCC	38.32	23684622
665	Phosphorylation	KPHEKPETRASKDHS CCCCCCCCCCCCCCC	39.81	28609623
668	Phosphorylation	EKPETRASKDHSGFR CCCCCCCCCCCCCCC	35.01	28066266
672	Phosphorylation	TRASKDHSGFRGNTI CCCCCCCCCCCCCCC	50.16	26643407
678	Phosphorylation	HSGFRGNTIPRGAAG CCCCCCCCCCCCHHH	34.87	26643407
681	Methylation	FRGNTIPRGAAGKIR CCCCCCCCCHHHHHH	43.46	18958509
712	Phosphorylation	RRNGKEQYVPPRSPK CCCCCCCCCCCCCCC	18.93	27180971
717	Phosphorylation	EQYVPPRSPK----- CCCCCCCCCC-----	42.70	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LARP4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LARP4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LARP4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LARP4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-717, AND MASSSPECTROMETRY.
PubMed: 19367708